ArticleComparative biochemistry and physiology. Toxicology & pharmacology : CBP2012
Zinc transporter expression in zebrafish (Danio rerio) during development.
Article in Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Dietary Zinc Supplementation Improves Growth, Antioxidant Capacity, Immunity, and Intestinal Health in Juvenile Black Carp (Biology · 2026Article
- Article
- Dietary Nano-ZnO Is Absorbed via Endocytosis and ZIP Pathways, Upregulates Lipogenesis, and Induces Lipotoxicity in the Intestine of Yellow Catfish.International journal of molecular sciences · 2021Article
- Adverse effects of parental zinc deficiency on metal homeostasis and embryonic development in a zebrafish model.The Journal of nutritional biochemistry · 2017Article
- Combinatorial effects of zinc deficiency and arsenic exposure on zebrafish (Danio rerio) development.PloS one · 2017Article
- Article
- Zinc transporter ZIP10 forms a heteromer with ZIP6 which regulates embryonic development and cell migration.The Biochemical journal · 2016Article
- Toxic Effects of Zinc Chloride on the Bone Development in Danio rerio (Hamilton, 1822).Frontiers in physiology · 2016Article
- Mother-Specific Signature in the Maternal Transcriptome Composition of Mature, Unfertilized Zebrafish Eggs.PloS one · 2016Article
- 3D imaging of transition metals in the zebrafish embryo by X-ray fluorescence microtomography.Metallomics : integrated biometal science · 2014Article
- Zebrafish in the sea of mineral (iron, zinc, and copper) metabolism.Frontiers in pharmacology · 2014Review
- Topographical analysis of reactive zinc in the central nervous system of adult zebrafish (Danio rerio).Zebrafish · 2013Article
- Reaction of metal-binding ligands with the zinc proteome: zinc sensors and N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine.Inorganic chemistry · 2012Article
- Article
- Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Zinc is a micronutrient important in several biological processes including growth and development. We have limited knowledge on the impact of maternal zinc deficiency on zinc and zinc regulatory mechanisms in the developing embryo due to a lack of in vivo experimental models that allow us to directly study the effects of maternal zinc on embryonic development following implantation. To overcome this barrier, we have proposed to use zebrafish as a model organism to study the impact of zinc during development. The goal of the current study was to profile the mRNA expression of all the known zinc transporter genes in the zebrafish across embryonic and larval development and to quantify the embryonic zinc concentrations at these corresponding developmental time points. The SLC30A zinc transporter family (ZnT) and SLC39A family, Zir-,Irt-like protein (ZIP) zinc transporter proteins were profiled in zebrafish embryos at 0, 2, 6, 12, 24, 48 and 120 h post fertilization to capture expression patterns from a single cell through full development. We observed consistent embryonic zinc levels, but differential expression of several zinc transporters across development. These results suggest that zebrafish is an effective model organism to study the effects of zinc deficiency and further investigation is underway to identify possible molecular pathways that are dysregulated with maternal zinc deficiency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.