Evidence map›Paper›PMID 21596039›Full record

ReviewExperimental neurology2012

Role of myelin-associated inhibitors in axonal repair after spinal cord injury.

Jae K Lee, Binhai Zheng

Abstract readReview
In one paragraph

Review in Experimental neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Repair mechanisms of the central nervous system: From axon sprouting to remyelination.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  8. Article
  9. Review
  10. Article
  11. NgR1 binding to reovirus reveals an unusual bivalent interaction and a new viral attachment protein.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  12. Review
  13. Injection of Cerium Oxide Nanoparticles to Treat Spinal Cord Injury in Rats.Journal of neuropathology and experimental neurology · 2022
    Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. AAV2-BDNF promotes respiratory axon plasticity and recovery of diaphragm function following spinal cord injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jae K LeeUniversity of California San Diego, Department of Neurosciences, 9500 Gilman Drive, MC 0691, La Jolla, CA 92093-0691, USA. JLee22@med.miami.edu
Binhai Zheng

Funding

Genetic analysis of myelin inhibitors and PTEN in injury-inducedCNS axon growthR01NS054734 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZHENG, BINHAI · 2007 to 2015
$3.2M
The role of semaphorins in the injured spinal cordF32NS056697 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LEE, JAE K · 2007 to 2009
$148k
NINDS NIH HHS F32 NS056697NINDS NIH HHS F32NS056697NINDS NIH HHS R01 NS054734NINDS NIH HHS R01NS054734
6 · The paper itself

Abstract

Myelin-associated inhibitors of axon growth, including Nogo, MAG and OMgp, have been the subject of intense research. A myriad of experimental approaches have been applied to investigate the potential of targeting these molecules to promote axonal repair after spinal cord injury. However, there are still conflicting results on their role in axon regeneration and therefore a lack of a cohesive mechanism on how these molecules can be targeted to promote axon repair. One major reason may be the lack of a clear definition of axon regeneration in the first place. Nevertheless, recent data from genetic studies in mice indicate that the roles of these molecules in CNS axon repair may be more intricate than previously envisioned.

Indexed as

AnimalsAxonsGPI-Linked ProteinsMiceMyelin-Associated GlycoproteinMyelin ProteinsNerve RegenerationNogo ProteinsSpinal Cord InjuriesGPI-Linked ProteinsMyelin-Associated GlycoproteinMyelin ProteinsNogo ProteinsOmg protein, mouseRtn4 protein, mouse

Identifiers

PMID21596039
PMCPMC3170678

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.