ArticleBMC biophysics2011
A solvable model for the diffusion and reaction of neurotransmitters in a synaptic junction.
Article in BMC biophysics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Computational modeling of trans-synaptic nanocolumns, a modulator of synaptic transmission.Frontiers in computational neuroscience · 2022Article
- Asymmetric high-order anatomical brain connectivity sculpts effective connectivity.Network neuroscience (Cambridge, Mass.) · 2020Article
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Authors and funding
2 authors.
Funding
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Abstract
backgroundThe diffusion and reaction of the transmitter acetylcholine in neuromuscular junctions and the diffusion and binding of Ca2+ in the dyadic clefts of ventricular myocytes have been extensively modeled by Monte Carlo simulations and by finite-difference and finite-element solutions. However, an analytical solution that can serve as a benchmark for testing these numerical methods has been lacking.
resultHere we present an analytical solution to a model for the diffusion and reaction of acetylcholine in a neuromuscular junction and for the diffusion and binding of Ca2+ in a dyadic cleft. Our model is similar to those previously solved numerically and our results are also qualitatively similar.
conclusionThe analytical solution provides a unique benchmark for testing numerical methods and potentially provides a new avenue for modeling biochemical transport.
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