ArticleBMC evolutionary biology2011
Evidence for the additions of clustered interacting nodes during the evolution of protein interaction networks from network motifs.
Article in BMC evolutionary biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Integrating protein interaction and pathway crosstalk network reveals a promising therapeutic approach for psoriasis through apoptosis induction.Scientific reports · 2024Article
- Exploration of Target Spaces in the Human Genome for Protein and Peptide Drugs.Genomics, proteomics & bioinformatics · 2022Article
- Function, dynamics and evolution of network motif modules in integrated gene regulatory networks of worm and plant.Nucleic acids research · 2018Article
- Comparison of large networks with sub-sampling strategies.Scientific reports · 2016Article
- Alignment-free protein interaction network comparison.Bioinformatics (Oxford, England) · 2014Article
- Proteome-wide prediction of self-interacting proteins based on multiple properties.Molecular & cellular proteomics : MCP · 2013Article
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Authors and funding
8 authors.
Funding
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Abstract
backgroundHigh-throughput screens have revealed large-scale protein interaction networks defining most cellular functions. How the proteins were added to the protein interaction network during its growth is a basic and important issue. Network motifs represent the simplest building blocks of cellular machines and are of biological significance.
resultsHere we study the evolution of protein interaction networks from the perspective of network motifs. We find that in current protein interaction networks, proteins of the same age class tend to form motifs and such co-origins of motif constituents are affected by their topologies and biological functions. Further, we find that the proteins within motifs whose constituents are of the same age class tend to be densely interconnected, co-evolve and share the same biological functions, and these motifs tend to be within protein complexes.
conclusionsOur findings provide novel evidence for the hypothesis of the additions of clustered interacting nodes and point out network motifs, especially the motifs with the dense topology and specific function may play important roles during this process. Our results suggest functional constraints may be the underlying driving force for such additions of clustered interacting nodes.
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