ArticleCritical care (London, England)2011
C-reactive protein in critically ill cancer patients with sepsis: influence of neutropenia.
Article in Critical care (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- Use of a computerized C-reactive protein (CRP) based sepsis evaluation in very low birth weight (VLBW) infants: a five-year experience.PloS one · 2013Trial
- Battle of the Biomarkers of Systemic Inflammation.Biology · 2025Review
- A Multicenter Investigation on the Incidence and Risk Factors of Wound Dehiscence Following Surgical Treatment of Metastatic Spinal Tumors: The Korean Society of Spinal Tumors Multicenter Study (KSST 2023-01).Journal of clinical medicine · 2025Article
- Septic shock in the immunocompromised cancer patient: a narrative review.Critical care (London, England) · 2024Review
- Biomarkers in pulmonary infections: a clinical approach.Annals of intensive care · 2024Review
- How to use biomarkers of infection or sepsis at the bedside: guide to clinicians.Intensive care medicine · 2023Review
- Dependence of the severity of the systemic inflammatory response on resistance to hypoxia in male Wistar rats.Journal of inflammation research · 2019Article
- Morphological Characteristics of the Thymus and Spleen and the Subpopulation Composition of Lymphocytes in Peripheral Blood during Systemic Inflammatory Response in Male Rats with Different Resistance to Hypoxia.International journal of inflammation · 2019Article
- Retrospective analysis of cancer patients admitted to a tertiary centre with suspected neutropenic sepsis: Are C-reactive protein and neutrophil count useful prognostic biomarkers?Journal of the Intensive Care Society · 2018Article
- Staphylococcus aureus bacteremia in immunosuppressed patients: a multicenter, retrospective cohort study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Article
- Clinical Utility and Measurement of Procalcitonin.The Clinical biochemist. Reviews · 2017Review
- Procalcitonin as diagnostic marker of infection in solid tumors patients with fever.Scientific reports · 2016Article
- Cardiac Troponin Is a Predictor of Septic Shock Mortality in Cancer Patients in an Emergency Department: A Retrospective Cohort Study.PloS one · 2016Article
- Pros and cons of using biomarkers versus clinical decisions in start and stop decisions for antibiotics in the critical care setting.Intensive care medicine · 2015Review
- Urinary neutrophil gelatinase-associated lipocalin in critically ill surgical cancer patients.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2015Article
- Article
- Using procalcitonin to guide antimicrobial duration in sepsis: asking the same questions will not bring different answers.Critical care (London, England) · 2014Article
- Diagnostic accuracy of lipopolysaccharide-binding protein for predicting bacteremia/clinical sepsis in children with febrile neutropenia: comparison with interleukin-6, procalcitonin, and C-reactive protein.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2014Article
- Biomarkers for sepsis: a review with special attention to India.BioMed research international · 2014Review
- Use of biomarkers in sepsis: many questions, few answers.Revista Brasileira de terapia intensiva · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSeveral biomarkers have been studied in febrile neutropenia. Our aim was to assess C-reactive protein (CRP) concentration in septic critically ill cancer patients and to compare those with and without neutropenia.
methodsA secondary analysis of a matched case-control study conducted at an oncologic medical-surgical intensive care unit (ICU) was performed, segregating patients with severe sepsis/septic shock. The impact of neutropenia on CRP concentrations at admission and during the first week of ICU stay was assessed.
resultsA total of 154 critically ill septic cancer patients, 86 with neutropenia and 68 without, were included in the present study. At ICU admission, the CRP concentration of neutropenic patients was significantly higher than in non-neutropenic patients, 25.9 ± 11.2 mg/dL vs. 19.7 ± 11.4 mg/dL (P = 0.009). Among neutropenic patients, CRP concentrations at ICU admission were not influenced by the severity of neutropenia (< 100/mm3 vs. ≥ 100/mm3 neutrophils), 25.1 ± 11.6 mg/dL vs. 26.9 ± 10.9 mg/dL (P = 0.527). Time dependent analysis of CRP from Day 1 to Day 7 of antibiotic therapy showed an almost parallel decrease in both groups (P = 0.335), though CRP of neutropenic patients was, on average, always higher in comparison to that of non-neutropenic patients.
conclusionsIn septic critically ill cancer patients CRP concentrations are more elevated in those with neutropenia. However, the CRP course seems to be independent from the presence or absence of neutropenia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.