ArticleMolecular ecology2011
Testing for causality in covarying traits: genes and latitude in a molecular world.
Article in Molecular ecology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Clock-talk: have we forgotten about geographic variation?Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Article
- EST-Microsatellite Types and Structural Scenarios in European Hake Fisheries.Animals : an open access journal from MDPI · 2022Article
- Keeping time without a spine: what can the insect clock teach us about seasonal adaptation?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- DNA methylation changes induced by long and short photoperiods in Nasonia.Genome research · 2016Article
- Latitudinal clines: an evolutionary view on biological rhythms.Proceedings. Biological sciences · 2013Review
- Geography of the circadian gene clock and photoperiodic response in western North American populations of the three-spined stickleback Gasterosteus aculeatus.Journal of fish biology · 2013Article
- Article
- Genetic change for earlier migration timing in a pink salmon population.Proceedings. Biological sciences · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Many traits are assumed to have a causal (necessary) relationship with one another because of their common covariation with a physiological, ecological or geographical factor. Herein, we demonstrate a straightforward test for inferring causality using residuals from regression of the traits with the common factor. We illustrate this test using the covariation with latitude of a proxy for the circadian clock and a proxy for the photoperiodic timer in Drosophila and salmon. A negative result of this test means that further discussion of the adaptive significance of a causal connection between the covarying traits is unwarranted. A positive result of this test provides a point of departure that can then be used as a platform from which to determine experimentally the underlying functional connections and only then to discuss their adaptive significance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.