ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2011
The identification of transcription factors expressed in the notochord of Ciona intestinalis adds new potential players to the brachyury gene regulatory network.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 47 citations in OpenAlex.
- Pair-rule-like transcription patterns during neural tube closure in a proto-vertebrate.Development (Cambridge, England) · 2025Article
- Fine-Tuned Expression of Evolutionarily Conserved Signaling Molecules in theInternational journal of molecular sciences · 2024Article
- Single-cell Transcriptomic Studies Unveil Potential Nodes of the Notochord Gene Regulatory Network.Integrative and comparative biology · 2024Review
- Cis-regulatory interfaces reveal the molecular mechanisms underlying the notochord gene regulatory network of Ciona.Nature communications · 2024Article
- Article
- Searching for marine embryos, finding my path.Genesis (New York, N.Y. : 2000) · 2023Article
- Gene expression in notochord and nuclei pulposi: a study of gene families across the chordate phylum.BMC ecology and evolution · 2023Article
- Nuclear Factor of Activated T Cells-5 Regulates Notochord Lumenogenesis in Chordate Larval Development.International journal of molecular sciences · 2022Article
- Article
- The Degenerate Tale of Ascidian Tails.Integrative and comparative biology · 2021Review
- Genome-Wide Identification, Comparison, and Expression Analysis of Transcription Factors in AscidianInternational journal of molecular sciences · 2021Article
- Brachyury controlsDevelopment (Cambridge, England) · 2021Article
- The AscidiaFrontiers in cell and developmental biology · 2021Article
- A single-cell analysis of the molecular lineage of chordate embryogenesis.Science advances · 2020Article
- Review
- The notochord gene regulatory network in chordate evolution: Conservation and divergence from Ciona to vertebrates.Current topics in developmental biology · 2020Review
- NFAT5/TonEBP controls early acquisition of notochord phenotypic markers, collagen composition, and sonic hedgehog signaling during mouse intervertebral disc embryogenesis.Developmental biology · 2019Article
- Positioning a multifunctional basic helix-loop-helix transcription factor within the Ciona notochord gene regulatory network.Developmental biology · 2019Article
- Single-cell transcriptome profiling of the Ciona larval brain.Developmental biology · 2019Article
- Multiple inputs into a posterior-specific regulatory network in the Ciona notochord.Developmental biology · 2019Article
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6 authors at 2 institutions in 2 countries.
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Abstract
The notochord is the distinctive characteristic of chordates; however, the knowledge of the complement of transcription factors governing the development of this structure is still incomplete. Here we present the expression patterns of seven transcription factor genes detected in the notochord of the ascidian Ciona intestinalis at various stages of embryonic development. Four of these transcription factors, Fos-a, NFAT5, AFF and Klf15, have not been directly associated with the notochord in previous studies, while the others, including Spalt-like-a, Lmx-like, and STAT5/6-b, display evolutionarily conserved expression in this structure as well as in other domains. We examined the hierarchical relationships between these genes and the transcription factor Brachyury, which is necessary for notochord development in all chordates. We found that Ciona Brachyury regulates the expression of most, although not all, of these genes. These results shed light on the genetic regulatory program underlying notochord formation in Ciona and possibly other chordates.
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