Evidence map›Paper›PMID 21594790›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2011

Analysis of CFTR interactome in the macromolecular complexes.

Chunying Li, Anjaparavanda P Naren

Abstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
24.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 26 citations in OpenAlex.

  1. Personalized medicine approaches in cystic fibrosis related pancreatitis.American journal of translational research · 2022
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  20. STAS domain structure and function.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2011
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Chunying LiDepartment of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA. cl@med.wayne.edu
Anjaparavanda P Naren
University of Tennessee Health Science Center · USWayne State University · US

Funding

Inhibition of an apical cAMP transporter (MRP4) in the gut induces diarrheaR01DK080834 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI Anjaparavanda P Naren · 2009 to 2026
$6.8M
LPA2 receptor-containing complexes in regulating secretory diarrheaR01DK093045 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI NAREN, ANJAPARAVANDA P · 2011 to 2019
$3.0M
Identifying molecules that augment mutant CFTR activityR01DK058545 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI NAREN, ANJAPARAVANDA P · 2002 to 2006
$1.1M
CFTR-dependent protein interactions regulate diarrheaR01DK074996 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI NAREN, ANJAPARAVANDA P · 2006 to 2009
$1.1M
NIDDK NIH HHS DK058545NIDDK NIH HHS DK074996NIDDK NIH HHS R01 DK058545NIDDK NIH HHS R01 DK074996NIDDK NIH HHS R01 DK080834NIDDK NIH HHS R01 DK093045
6 · The paper itself

Abstract

Cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel localized primarily at the apical surface of epithelial cells lining the airway, gut, exocrine glands, etc., where it is responsible for transepithelial salt and water transport. A growing number of proteins have been reported to interact directly or indirectly with CFTR chloride channel, suggesting that CFTR might regulate the activities of other ion channels, receptors, and transporters, in addition to its role as a chloride conductor. Most interactions occur primarily between the opposing terminal tails (N or C) of CFTR and its binding partners, either directly or mediated through various PDZ domain-containing proteins. This chapter describes methods we developed to cross-link CFTR into a macromolecular complex to identify and analyze the assembly and regulation of CFTR-containing complexes in the plasma membrane.

Indexed as

AnimalsCell LineCell MembraneCystic Fibrosis Transmembrane Conductance RegulatorEscherichia coliHumansPhosphoproteinsProtein Interaction MappingProtein Structure, TertiarySodium-Hydrogen ExchangersCystic Fibrosis Transmembrane Conductance RegulatorPhosphoproteinssodium-hydrogen exchanger regulatory factorSodium-Hydrogen Exchangers

Identifiers

PMID21594790
PMCPMC3178881
OpenAlexW1538940252

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.