ReviewImmunogenetics2011
Molecular bases of genetic diversity and evolution of the immunoglobulin heavy chain variable region (IGHV) gene locus in leporids.
Review in Immunogenetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 34 citations in OpenAlex.
- An update on the characterization of immunoglobulin loci inFrontiers in immunology · 2026Article
- The evolutionary history of IGKC in mammals reveals ancient duplications and remarkable divergence in lagomorphs.Frontiers in immunology · 2025Article
- The rabbit as an animal model to study innate immunity genes: Is it better than mice?Frontiers in immunology · 2022Article
- Mystifying Molecular Structure, Expression and Repertoire Diversity of IgM Heavy Chain Genes (Frontiers in immunology · 2022Article
- Genetic Diversity ofAnimals : an open access journal from MDPI · 2019Article
- Rabbit models of human diseases for diagnostics and therapeutics development.Developmental and comparative immunology · 2019Review
- The wide utility of rabbits as models of human diseases.Experimental & molecular medicine · 2018Review
- LaGomiCs-Lagomorph Genomics Consortium: An International Collaborative Effort for Sequencing the Genomes of an Entire Mammalian Order.The Journal of heredity · 2016Review
- An overview of the lagomorph immune system and its genetic diversity.Immunogenetics · 2016Review
- Molecular characterization and analysis of TLR-1 in rabbit tissues.Central-European journal of immunology · 2016Article
- Genetic characterization of interleukins (IL-1α, IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphs.Innate immunity · 2015Article
- Genetic diversity comparison of the DQA gene in European rabbit (Oryctolagus cuniculus) populations.Immunogenetics · 2015Article
- Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site.PLoS pathogens · 2015Article
- Trans-Species Polymorphism in Immune Genes: General Pattern or MHC-Restricted Phenomenon?Journal of immunology research · 2015Review
- Article
- Sequencing of Sylvilagus VDJ genes reveals a new VHa allelic lineage and shows that ancient VH lineages were retained differently in leporids.Immunogenetics · 2014Article
- Hematopoiesis in the equine fetal liver suggests immune preparedness.Immunogenetics · 2014Article
- Convergent evolution of IL-6 in two leporids (Oryctolagus and Pentalagus) originated an extended protein.Immunogenetics · 2014Article
- Leporid immunoglobulin G shows evidence of strong selective pressure on the hinge and CH3 domains.Open biology · 2014Article
- Multi-parameter exploration of HIV-1 virus-like particles as neutralizing antibody immunogens in guinea pigs, rabbits and macaques.Virology · 2014Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
The rabbit has long been a model for studies of the immune system. Work using rabbits contributed both to the battle against infectious diseases such as rabies and syphilis, and to our knowledge, of antibodies' structure, function, and regulated expression. With the description of rabbit Ig allotypes, the discovery of different gene segments encoding immunoglobulins became possible. This challenged the "one gene-one protein" dogma. The observation that rabbit allotypic specificities of the variable regions were present on IgM and IgG molecules also led to the hypothesis of Ig class switching. Rabbit allotypes contributed to the documentation of phenomena such as allelic exclusion and imbalance in production of allelic gene products. During the last 30 years, the rabbit Ig allotypes revealed a number of unique features, setting them apart from mice, humans, and other mammals. Here, we review the most relevant findings concerning the rabbit IGHV. Among these are the preferential usage of one VH gene in VDJ rearrangements, the existence of trans-species polymorphism in the IGHV locus revealed by serology and confirmed by sequencing IGHV genes in Lepus, the unusually large genetic distances between allelic lineages and the fact that the antibody repertoire is diversified in this species only after birth. The whole genome sequence of a rabbit, plus re-sequencing of additional strains and related genera, will allow further evolutionary investigations of antibody variation. Continued research will help define the roles that genetic, allelic, and population diversity at antibody loci may play in host-parasite interactions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.