Trial reportThe international journal of cardiovascular imaging2012
Relationship between cardiovascular risk factors and biomarkers with necrotic core and atheroma size: a serial intravascular ultrasound radiofrequency data analysis.
Trial report in The international journal of cardiovascular imaging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Phenotyping atherosclerotic plaque and perivascular adipose tissue: signalling pathways and clinical biomarkers in atherosclerosis.Nature reviews. Cardiology · 2025Review
- CT-derived fractional flow reserve for prediction of major adverse cardiovascular events in diabetic patients.Cardiovascular diabetology · 2023Article
- Pathophysiology of Atherosclerosis.International journal of molecular sciences · 2022Review
- HbA1c, Coronary atheroma progression and cardiovascular outcomes.American journal of preventive cardiology · 2022Article
- NaF-PET/CT global assessment in detecting and quantifying subclinical cardiac atherosclerosis and its association with blood pressure in non-dyslipidemic individuals.American journal of cardiovascular disease · 2020Article
- Diastolic blood pressure predicts coronary plaque volume in patients with coronary artery disease.Atherosclerosis · 2018Article
- Article
- The association of hemoglobin A1c and high risk plaque and plaque extent assessed by coronary computed tomography angiography.The international journal of cardiovascular imaging · 2016Article
- Targeting inflammation: impact on atherothrombosis.Journal of cardiovascular translational research · 2014Review
- Virtual histology assessment of coronary atheroma influences treatment strategy in the young acute coronary syndrome patient.BMJ case reports · 2014Article
- Cardiovascular imaging 2012 in the International Journal of Cardiovascular Imaging.The international journal of cardiovascular imaging · 2013Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We explored the impact of patient demographics, anthropometric measurements, cardiovascular risk factors, and soluble biomarkers on necrotic core and atheroma size in patients with coronary disease. The IBIS-2 trial enrolled 330 patients. In the multivariate analysis, at baseline, creatinine had a positive, whereas baseline mean lumen diameter and myeloperoxidase had a negative, independent association with percentage of necrotic core (PNC); while age, glomerular filtration rate <60, HbA1c, previous PCI or CABG and baseline % diameter stenosis were positively, and acute coronary syndromes (ACS) were negatively associated with baseline percentage atheroma volume (PAV). The variables associated with a decrease in PNC from baseline were darapladib, ACS and a large content of NC at baseline, while variables associated with an increase in PNC were previous stroke and % diameter stenosis at baseline. Those variables associated with a decrease in PAV from baseline were waist circumference, statin use, CD40L and baseline PAV, while the only variable associated with an increase in PAV was baseline diastolic blood pressure. Treatment with darapladib was associated with a decrease in necrotic core, but was not associated with a decrease in percentage atheroma volume. On the contrary, statin use was only associated with a decrease in percentage atheroma volume.
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