SynthesisJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2011
Cardiac resynchronization therapy in patients with mild heart failure: a systematic review and meta-analysis.
Synthesis in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Image-guided left ventricular lead placement in cardiac resynchronization therapy for patients with heart failure: a meta-analysis.BMC cardiovascular disorders · 2015Pooled it
- Cryoablation versus radiofrequency ablation of atrioventricular nodal reentrant tachycardia.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2014Pooled it
- Left Bundle Branch Block as a Risk Factor for Heart Failure.JAMA network open · 2025Article
- Trajectories in New York Heart Association functional class in heart failure across the ejection fraction spectrum: data from the Swedish Heart Failure Registry.European journal of heart failure · 2022Article
- Orthodromic and Antidromic Snare Techniques for Left Ventricular Lead Implantation in Cardiac Resynchronization Therapy.Journal of clinical medicine · 2022Article
- Prophylactic implantable cardioverter defibrillator in heart failure: the growing evidence for all or Primum non nocere for some?Heart failure reviews · 2017Review
- Cost-Effectiveness of Adding Cardiac Resynchronization Therapy to an Implantable Cardioverter-Defibrillator Among Patients With Mild Heart Failure.Annals of internal medicine · 2015Article
- Use of Cardiac Resynchronisation Therapy - Change of Clinical Settings.Arrhythmia & electrophysiology review · 2014Article
- Outcomes in Women Undergoing Electrophysiological Procedures.Arrhythmia & electrophysiology review · 2013Article
- Advances in catheter ablation: atrial fibrillation ablation in patients with mitral mechanical prosthetic valve.Current cardiology reviews · 2012Review
- Electrical devices for left ventricular dysfunction and heart failure: do we need revised guidelines?Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2012Article
- The emerging role of cardiac resynchronization therapy in milder heart failure: are we implanting too late for response?Current heart failure reports · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCardiac resynchronization therapy (CRT) reduces symptoms and improves survival in patients with advanced heart failure (New York Heart Association (NYHA) functional class III-IV), reduced ejection fraction, and wide QRS complex. Whether CRT has the same benefit also in asymptomatic or mildly symptomatic heart failure patients is controversial. Our objective is to summarize the available evidence on the effects of CRT in asymptomatic or mildly symptomatic (NYHA I-II) heart failure patients.
methodsWe searched major web databases for randomized controlled trials of CRT in patients with mild heart failure (NYHA functional class I-II). Data regarding all-cause mortality, heart failure events, left ventricular (LV) volumes and ejection fraction, and worsening of NYHA functional class were extracted.
resultsWe identified five trials (CONTAK-CD, MIRACLE ICD-II, REVERSE, MADIT-CRT, and RAFT) that enrolled 4,213 patients (91% with NYHA II functional class). Primary analysis excluded the CONTAK-CD, which was not specifically conducted on patients with mild heart failure. At pooled analysis, CRT decreased mortality (odds ratio (OR), 0.78 [95% confidence interval (CI)], 0.63 to 0.97; p = 0.024) and heart failure events (OR, 0.63 [95% CI, 0.52 to 0.76], p < 0.001), induced a significant LV reverse remodeling (weighted mean difference (WMD) of LV ejection fraction [Formula: see text], p = 0.015 and WMD of LV end-systolic volume index [Formula: see text], p < 0.001) and prevented the progression of heart failure symptoms (OR for worsening of NYHA functional class = 0.54 [95% CI, 0.31 to 0.93], p = 0.026). Inclusion of the CONTAK-CD did not change the results.
conclusionsAmong patients with mild (NYHA II) heart failure, CRT reduces mortality and the risk of heart failure events, induces a favorable LV reverse remodeling and slows the progression of heart failure symptoms.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.