ArticleUrological research2012
Urinary pH and renal lithiasis.
Article in Urological research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Role, Cost, and Availably of Urinary pH Monitoring for Kidney Stone Disease-A Systematic Review of the Literature.Current urology reports · 2023Pooled it
- Comparison of Two Dietary Supplements for Treatment of Uric Acid Renal Lithiasis: Citrate vs. Citrate + Theobromine.Nutrients · 2020Trial
- Recent advances of wearable electrochemical and optical sensors for sweat pH monitoring.RSC advances · 2026Review
- Coexistence of virome-encoded health-associated genes and pathogenic genes in global habitats.Applied and environmental microbiology · 2025Article
- Diversity and distribution of extracellular microcrystals in holothuroid echinoderms.Royal Society open science · 2025Article
- Therapeutic potential of seaweeds and their biofabricated nanoparticles in treating urolithiasis: A review.Heliyon · 2025Review
- The Impact of Stone Composition on Treatment Strategies for Patients with Urolithiasis: A Narrative Review.Cureus · 2024Review
- Urinary exosomes: a promising biomarker of drug-induced nephrotoxicity.Frontiers in medicine · 2023Review
- Review
- Differences of Uric Acid Transporters Carrying Extracellular Vesicles in the Urine from Uric Acid and Calcium Stone Formers and Non-Stone Formers.International journal of molecular sciences · 2022Article
- Machine Learning Prediction of Kidney Stone Composition Using Electronic Health Record-Derived Features.Journal of endourology · 2022Article
- Activatable NIR-II organic fluorescent probes for bioimaging.Theranostics · 2022Review
- Fasting and 24-h urine pH in patients with urolithiasis using potassium citrate.American journal of clinical and experimental urology · 2022Article
- Urine and stone analysis for the investigation of the renal stone former: a consensus conference.Urolithiasis · 2021Article
- Predicting the risk of kidney stone formation in the nephron by 'reverse engineering'.Urolithiasis · 2020Article
- Educational review: role of the pediatric nephrologists in the work-up and management of kidney stones.Pediatric nephrology (Berlin, Germany) · 2020Review
- Size-Dependent Cytotoxicity of Hydroxyapatite Crystals on Renal Epithelial Cells.International journal of nanomedicine · 2020Article
- Effect of sample time on urinary lithogenic risk indexes in healthy and stone-forming adults and children.BMC urology · 2018Article
- Systematic evaluation for effects of urine pH on calcium oxalate crystallization, crystal-cell adhesion and internalization into renal tubular cells.Scientific reports · 2017Article
- Association of serum electrolytes and smoking with salivary gland stone formation.International journal of oral and maxillofacial surgery · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Formation of calcium oxalate crystals, either as monohydrate or dihydrate, is apparently unrelated to urinary pH because the solubilities of these salts are practically unaltered at physiologic urinary pH values. However, a urinary pH <5.5 or >6.0 may induce uric acid or calcium phosphate crystals formation, respectively, which under appropriate conditions may induce the development of the calcium oxalate calculi. We assessed the relationship between the urinary pH and the formation of different types of calculi. A retrospective study in 1,478 patients was done. We determined the composition, macrostructure, and microstructure of the calculi and the urinary pH, 50.9% of calcium oxalate monohydrate unattached calculi were present in patients with urinary pH <5.5. We found that 34.1 and 41.5% of calcium oxalate dihydrate calculi were present in patients with urinary pH <5.5 and >6.0, respectively. Infectious calculi were found primarily in patients with urinary pH >6.0 (50.7%). Only calcium oxalate monohydrate papillary calculi were associated with urinary pH between 5.5 and 6.0 (43.1%). Urine of pH <5.5 shows an increased capacity to develop uric acid crystals, which can act as a heterogeneous nuclei of calcium oxalate crystals. In contrast, urine of pH >6.0 has an increased capacity to develop calcium phosphate crystals, which can act as a heterogeneous nuclei of calcium oxalate crystals. Oxalate monohydrate papillary calculi were associated to pH between 5.5 and 6.0 because the injured papilla acts as a heterogeneous nucleant. Consequently, measurement of urinary pH may be used to evaluate the lithogen risk of given urine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.