ArticlePLoS genetics2011
Phosphorylation-dependent differential regulation of plant growth, cell death, and innate immunity by the regulatory receptor-like kinase BAK1.
Article in PLoS genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 247 papers.
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Who cites it
247 citing papers in PubMed, 538 citations in OpenAlex.
- Mechanisms and balanced regulation of plant immunity.Nature reviews. Molecular cell biology · 2026Review
- An LRR co-receptor kinase essential for systemic nitrogen-demand signalling.Nature plants · 2026Article
- Redox Regulation of Plant-Root-Knot Nematode Interactions: From ROS-Mediated Immunity to Sustainable Resistance.Antioxidants (Basel, Switzerland) · 2026Review
- Puccinia triticina Effector Pt3863 Targets and Subverts TaRLCK176 to Suppress Wheat Resistance to Leaf Rust.Molecular plant pathology · 2026Article
- Membrane remodelling mediates lipopeptide-induced immunity in Arabidopsis.Nature plants · 2026Article
- Plant cell surface receptors.The Plant journal : for cell and molecular biology · 2026Review
- Identification of Phosphorylation and Protein Interactions of Plant Pattern Recognition Receptors Through Immunoprecipitation.Methods in molecular biology (Clifton, N.J.) · 2026Article
- The Arabidopsis phosphatase PP2C12 negatively regulates LRX-RALF-FER-mediated cell wall integrity sensing.The EMBO journal · 2026Article
- Wheat Plasma Membrane Receptors: Orchestrating Immunity and Bridging to Crop Improvement.Current issues in molecular biology · 2025Review
- ZmBAK1 confers maize resistance toPlant signaling & behavior · 2025Article
- Cyclic-di-GMP controls Type III effector export and symptom development in Pseudomonas syringae infections via the export ATPase HrcN.PLoS pathogens · 2025Article
- SERK5 genetically compensates for the loss of BAK1 and BKK1 in regulating elf18-triggered immune signaling inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- A fungal pathogen manipulates phytocytokine signaling for plant infection.Nature communications · 2025Article
- Chitin Soil Amendment Triggers Systemic Plant Disease Resistance Through Enhanced Pattern-Triggered Immunity.Plant biotechnology journal · 2025Article
- Mastering the balance: BAK1's dual roles in steering plant growth and immunity.Horticulture research · 2025Article
- Oomycetes manipulate plant innate immunity through galacturonide oxidases.Nature communications · 2025Article
- Overexpression of the Receptor-Like Kinase BIR1 Causes SOBIR1- and EDS1-Dependent Cell Death Phenotypes in Arabidopsis.Plant, cell & environment · 2025Article
- Aphid effector Mp10 balances immune suppression and defence activation through EDS1-dependent modulation of plant DAMP responses.The New phytologist · 2025Article
- A trehalase-derived MAMP triggers LecRK-V-mediated immune responses inScience advances · 2025Article
- Physiological, biochemical, and transcriptomic analyses reveal potential candidate genes of Platostoma palustre in response to salt stress.BMC plant biology · 2025Article
187 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants rely heavily on receptor-like kinases (RLKs) for perception and integration of external and internal stimuli. The Arabidopsis regulatory leucine-rich repeat RLK (LRR-RLK) BAK1 is involved in steroid hormone responses, innate immunity, and cell death control. Here, we describe the differential regulation of three different BAK1-dependent signaling pathways by a novel allele of BAK1, bak1-5. Innate immune signaling mediated by the BAK1-dependent RKs FLS2 and EFR is severely compromised in bak1-5 mutant plants. However, bak1-5 mutants are not impaired in BR signaling or cell death control. We also show that, in contrast to the RD kinase BRI1, the non-RD kinases FLS2 and EFR have very low kinase activity, and we show that neither was able to trans-phosphorylate BAK1 in vitro. Furthermore, kinase activity for all partners is completely dispensable for the ligand-induced heteromerization of FLS2 or EFR with BAK1 in planta, revealing another pathway specific mechanistic difference. The specific suppression of FLS2- and EFR-dependent signaling in bak1-5 is not due to a differential interaction of BAK1-5 with the respective ligand-binding RK but requires BAK1-5 kinase activity. Overall our results demonstrate a phosphorylation-dependent differential control of plant growth, innate immunity, and cell death by the regulatory RLK BAK1, which may reveal key differences in the molecular mechanisms underlying the regulation of ligand-binding RD and non-RD RKs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.