ArticleCell death & disease2011
PKCη promotes a proliferation to differentiation switch in keratinocytes via upregulation of p27Kip1 mRNA through suppression of JNK/c-Jun signaling under stress conditions.
Article in Cell death & disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Protein Kinase C Family: Structures, Biological Functions, Diseases, and Pharmaceutical Interventions.MedComm · 2025Review
- Effect of Hypertrophic Scar Fibroblast-Derived Exosomes on Keratinocytes of Normal Human Skin.International journal of molecular sciences · 2023Article
- Effect of extracorporeal shock wave therapy on keratinocytes derived from human hypertrophic scars.Scientific reports · 2021Article
- Pathological role of excessive DNA as a trigger of keratinocyte proliferation in psoriasis.Clinical and experimental immunology · 2020Article
- Anti-Aging Effects of GDF11 on Skin.International journal of molecular sciences · 2020Review
- Context-dependent effect of sPLAEBioMedicine · 2019Article
- The Enigmatic Protein Kinase C-eta.Cancers · 2019Review
- Polarized retinal pigment epithelium generates electrical signals that diminish with age and regulate retinal pathology.Journal of cellular and molecular medicine · 2018Article
- KMT2D regulates p63 target enhancers to coordinate epithelial homeostasis.Genes & development · 2018Article
- MAPK Pathway Involved in Epidermal Terminal Differentiation of Normal Human Epidermal Keratinocytes.Open medicine (Warsaw, Poland) · 2018Article
- Article
- Ingenol Disoxate: A Novel 4-Isoxazolecarboxylate Ester of Ingenol with Improved Properties for Treatment of Actinic Keratosis and Other Non-Melanoma Skin Cancers.Dermatology and therapy · 2016Article
- Absence of catalytic domain in a putative protein kinase C (PkcA) suppresses tip dominance in Dictyostelium discoideum.Developmental biology · 2015Article
- Low expression of chloride channel accessory 1 predicts a poor prognosis in colorectal cancer.Cancer · 2015Article
- Knockdown of filaggrin influences the epidermal terminal differentiation via MAPK pathway in normal human epidermal keratinocytes.Molecular biology reports · 2015Article
- miR-24 affects hair follicle morphogenesis targeting Tcf-3.Cell death & disease · 2013Article
- The transition from proliferation to differentiation in colorectal cancer is regulated by the calcium activated chloride channel A1.PloS one · 2013Article
- Novel transglutaminase 1 mutations in patients affected by lamellar ichthyosis.Cell death & disease · 2012Article
- The miR-17 family links p63 protein to MAPK signaling to promote the onset of human keratinocyte differentiation.PloS one · 2012Article
- From quiescence to proliferation: Cdk oscillations drive the mammalian cell cycle.Frontiers in physiology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To maintain epidermal homeostasis, the balance between keratinocyte proliferation and differentiation is tightly controlled. However, the molecular mechanisms underlying this balance remain unclear. In 3D organotypic coculture with mouse keratinocytes and fibroblasts, the thickness of stratified cell layers was prolonged, and growth arrest and terminal differentiation were delayed when PKCη-null keratinocytes were used. Re-expression of PKCη in PKCη-null keratinocytes restored stratified cell layer thickness, growth arrest and terminal differentiation. We show that in 3D cocultured PKCη-null keratinocytes, p27(Kip1) mRNA was downregulated, whereas JNK/c-Jun signaling was enhanced. Furthermore, inhibition of JNK/c-Jun signaling in PKCη-null keratinocytes led to upregulation of p27(Kip1) mRNA, and to thinner stratified cell layers. Collectively, our findings indicate that PKCη upregulates p27(Kip1) mRNA through suppression of JNK/c-Jun signaling. This results in promoting a proliferation to differentiation switch in keratinocytes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.