ArticleThe Clinical journal of pain
Altered central sensitization in subgroups of women with vulvodynia.
Article in The Clinical journal of pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 75 citations in OpenAlex.
- Molecular mechanisms and therapeutic perspectives in vulvodynia: From current evidence to future investigations.Cell reports. Medicine · 2026Review
- Chronic stress increases the susceptibility to chronic vulvar pain following acute vulvar inflammation in a preclinical model of vulvodynia.Molecular brain · 2026Article
- Vestibulodynia presentation is differentiated by the presence of additional chronic primary pain conditions.The journal of pain · 2025Article
- Impact of deep or ovarian endometriosis on pelvic pain and quality of life: prospective cross-sectional ultrasound study.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025Article
- Article
- Exploratory Study on Central Sensitization and Bioelectrical Activity of the Selected Masticatory Muscles in Subjects with Myopia.International journal of environmental research and public health · 2023Article
- Methodology of the INVestigating traIning assoCiated blasT pAthology (INVICTA) study.BMC medical research methodology · 2022Article
- Vulvodynia: Pain Management Strategies.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Characterization of Early Inflammatory Events Leading to Provoked Vulvodynia Development in Rats.Journal of inflammation research · 2022Article
- Chronic Neurophysiological Effects of Repeated Head Trauma in Retired Australian Male Sport Athletes.Frontiers in neurology · 2021Article
- Repeated Vaginal Exposures to the Common Cosmetic and Household Preservative Methylisothiazolinone Induce Persistent, Mast Cell-Dependent Genital Pain in ND4 Mice.International journal of molecular sciences · 2019Article
- Methodological approaches to botulinum toxin for the treatment of chronic pelvic pain, vaginismus, and vulvar pain disorders.International urogynecology journal · 2019Review
- Disease-Related Microstructural Differences in the Brain in Women With Provoked Vestibulodynia.The journal of pain · 2018Article
- An Undergraduate Laboratory Exercise that Demonstrates the Difference Between Peripherally and Centrally Mediated Measures.Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2016Article
- Article
- Prevalence and use of complementary health approaches among women with chronic pelvic pain in a prospective cohort study.Pain medicine (Malden, Mass.) · 2015Article
- Percept of the duration of a vibrotactile stimulus is altered by changing its amplitude.Frontiers in systems neuroscience · 2015Article
- Stimulating somatosensory psychophysics: a double-blind, sham-controlled study of the neurobiological mechanisms of tDCS.Frontiers in cellular neuroscience · 2015Article
- Vibrotactile discriminative capacity is impacted in a digit-specific manner with concurrent unattended hand stimulation.Experimental brain research · 2014Article
- Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo investigate the clinical correlates of central nervous system alterations among women with vulvodynia. Altered central sensitization has been linked to dysfunction in central nervous system-inhibitory pathways (e.g., γ-aminobutyric acidergic), and metrics of sensory adaptation, a centrally mediated process that is sensitive to this dysfunction, could potentially be used to identify women at risk of treatment failure using conventional approaches.
methodsTwelve women with vulvodynia and 20 age-matched controls participated in this study, which was conducted by sensory testing of the right hand's index and middle fingers. The following sensory precepts were assessed: (1) vibrotactile detection threshold; (2) amplitude discrimination capacity (defined as the ability to detect differences in intensity of simultaneously delivered stimuli to 2 fingers); and (3) a metric of adaptation (determined by the impact that applying conditioning stimuli have on amplitude discriminative capacity).
resultsParticipants did not differ on key demographic variables, vibrotactile detection threshold, and amplitude discrimination capacity. However, we found significant differences from controls in adaptation metrics in 1 subgroup of vulvodynia patients. Compared with healthy controls and women with a shorter history of pain [n=5; duration (y) = 3.4 ± 1.3], those with a longer history [n=7; duration (y) = 9.3 ± 1.4)] were found to be less likely to have adaptation metrics similar to control values. DISCUSSION: Chronic pain is thought to lead to altered central sensitization, and adaptation is a centrally mediated process that is sensitive to this condition. This report suggests that similar alterations exist in a subgroup of vulvodynia patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.