ReviewJournal of neural engineering2011
Encoding visual information in retinal ganglion cells with prosthetic stimulation.
Review in Journal of neural engineering, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Seeing anew: Mechanisms, outcomes, and challenges in adapting to restored sight via visual prostheses.Progress in retinal and eye research · 2026Review
- Population-scale analysis of frequency-dependent calcium dynamics in retinal ganglion cells under electric field stimulation.Scientific reports · 2026Article
- Population-Scale Analysis of Frequency-Dependent Calcium Dynamics in Retinal Ganglion Cells Under Electric Field Stimulation.bioRxiv : the preprint server for biology · 2026Article
- Spatial variation of evoked potentials in porcine retinas characterized by multi electrode array upon stimulation via 3D pyrolytic carbon electrodes.Frontiers in neuroscience · 2026Article
- Optimizing electrical stimulation parameters to enhance visual cortex activation in retina degeneration rats.Scientific reports · 2025Article
- Spatially Localized Visual Perception Estimation by Means of Prosthetic Vision Simulation.Journal of imaging · 2024Article
- Impact of Retinal Degeneration on Response of ON and OFF Cone Bipolar Cells to Electrical Stimulation.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2023Article
- Artificial Visual Information Produced by Retinal Prostheses.Frontiers in cellular neuroscience · 2022Review
- Morphological Factors that Underlie Neural Sensitivity to Stimulation in the Retina.Advanced nanobiomed research · 2021Article
- Monitoring Visual Cortical Activities During Progressive Retinal Degeneration Using Functional Bioluminescence Imaging.Frontiers in neuroscience · 2021Article
- Targeted Stimulation of Retinal Ganglion Cells in Epiretinal Prostheses: A Multiscale Computational Study.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2020Article
- Retinal Degeneration Reduces Consistency of Network-Mediated Responses Arising in Ganglion Cells to Electric Stimulation.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2020Article
- A model of ganglion axon pathways accounts for percepts elicited by retinal implants.Scientific reports · 2019Article
- Scaling of the AIS and Somatodendritic Compartments in α S RGCs.Frontiers in cellular neuroscience · 2019Article
- Direct measurement of bipolar cell responses to electrical stimulation in wholemount mouse retina.Journal of neural engineering · 2018Article
- Closed-Loop Efficient Searching of Optimal Electrical Stimulation Parameters for Preferential Excitation of Retinal Ganglion Cells.Frontiers in neuroscience · 2018Article
- Clinical Impact of Spontaneous Hyperactivity in Degenerating Retinas: Significance for Diagnosis, Symptoms, and Treatment.Frontiers in cellular neuroscience · 2018Article
- Activation of ganglion cells and axon bundles using epiretinal electrical stimulation.Journal of neurophysiology · 2017Article
- Amplitude Modulation-based Electrical Stimulation for Encoding Multipixel Spatiotemporal Visual Information in Retinal Neural Activities.Journal of Korean medical science · 2017Article
- A Sub-millimeter, Inductively Powered Neural Stimulator.Frontiers in neuroscience · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Retinal prostheses aim to restore functional vision to those blinded by outer retinal diseases using electric stimulation of surviving retinal neurons. The ability to replicate the spatiotemporal pattern of ganglion cell spike trains present under normal viewing conditions is presumably an important factor for restoring high-quality vision. In order to replicate such activity with a retinal prosthesis, it is important to consider both how visual information is encoded in ganglion cell spike trains, and how retinal neurons respond to electric stimulation. The goal of the current review is to bring together these two concepts in order to guide the development of more effective stimulation strategies. We review the experiments to date that have studied how retinal neurons respond to electric stimulation and discuss these findings in the context of known retinal signaling strategies. The results from such in vitro studies reveal the advantages and disadvantages of activating the ganglion cell directly with the electric stimulus (direct activation) as compared to activation of neurons that are presynaptic to the ganglion cell (indirect activation). While direct activation allows high temporal but low spatial resolution, indirect activation yields improved spatial resolution but poor temporal resolution. Finally, we use knowledge gained from in vitro experiments to infer the patterns of elicited activity in ongoing human trials, providing insights into some of the factors limiting the quality of prosthetic vision.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.