ArticleProceedings of the National Academy of Sciences of the United States of America2011
Active multistage coarsening of actin networks driven by myosin motors.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.
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Who cites it
97 citing papers in PubMed.
- Contractile to extensile transitions and mechanical adaptability enabled by activity in cytoskeletal structures.bioRxiv : the preprint server for biology · 2026Article
- Investigating active dynamics of contractile actomyosin gels with micro particle image velocimetry (micro-PIV) analysis.Scientific reports · 2026Article
- Light-induced assembly and repeatable actuation in CaNature communications · 2026Article
- Optogenetic actin network assembly on lipid bilayer uncovers the network density-dependent functions of actin-binding proteins.Nature communications · 2025Article
- Article
- Direct detection of deformation modes on varying length scales in active biopolymer networks.bioRxiv : the preprint server for biology · 2025Article
- Review
- ATP-induced reconfiguration of the micro-viscoelasticity of cardiac and skeletal myosin solutions.Applied physics letters · 2024Article
- Limiting pool and actin architecture controls myosin cluster sizes in adherent cells.Biophysical journal · 2024Article
- Self-assembled active actomyosin gels spontaneously curve and wrinkle similar to biological cells and tissues.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A deep learning framework for quantitative analysis of actin microridges.NPJ systems biology and applications · 2023Article
- Myosin and [Formula: see text]-actinin regulation of stress fiber contractility under tensile stress.Scientific reports · 2023Article
- The crucial role of adhesion in the transmigration of active droplets through interstitial orifices.Nature communications · 2023Article
- Next Generation Opto-Jasplakinolides Enable Local Remodeling of Actin Networks.Angewandte Chemie (International ed. in English) · 2022Article
- F-actin architecture determines constraints on myosin thick filament motion.Nature communications · 2022Article
- Nucleation causes an actin network to fragment into multiple high-density domains.Biophysical journal · 2022Article
- Emergence of local irreversibility in complex interacting systems.Physical review. E · 2022Article
- Reconstituting and Characterizing Actin-Microtubule Composites with Tunable Motor-Driven Dynamics and Mechanics.Journal of visualized experiments : JoVE · 2022Article
- 3D printed protein-based robotic structures actuated by molecular motor assemblies.Nature materials · 2022Article
- A generalized Flory-Stockmayer kinetic theory of connectivity percolation and rigidity percolation of cytoskeletal networks.PLoS computational biology · 2022Article
37 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
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Abstract
In cells, many vital processes involve myosin-driven motility that actively remodels the actin cytoskeleton and changes cell shape. Here we study how the collective action of myosin motors organizes actin filaments into contractile structures in a simplified model system devoid of biochemical regulation. We show that this self-organization occurs through an active multistage coarsening process. First, motors form dense foci by moving along the actin network structure followed by coalescence. Then the foci accumulate actin filaments in a shell around them. These actomyosin condensates eventually cluster due to motor-driven coalescence. We propose that the physical origin of this multistage aggregation is the highly asymmetric load response of actin filaments: they can support large tensions but buckle easily under piconewton compressive loads. Because the motor-generated forces well exceed this threshold, buckling is induced on the connected actin network that resists motor-driven filament sliding. We show how this buckling can give rise to the accumulation of actin shells around myosin foci and subsequent coalescence of foci into superaggregates. This new physical mechanism provides an explanation for the formation and contractile dynamics of disordered condensed actomyosin states observed in vivo.
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