ArticleJournal of neurophysiology2011
Dipole source analyses of laser evoked potentials obtained from subdural grid recordings from primary somatic sensory cortex.
Article in Journal of neurophysiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Reliable Biomarkers of Descending Pain Inhibition: A Laser-Evoked Potential and Behavioural Study.European journal of pain (London, England) · 2026Article
- Distinct neocortical mechanisms underlie human SI responses to median nerve and laser-evoked peripheral activation.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Effects of anesthetics on nociceptive sensory evoked potentials by intraepidermal noxious electrical stimulation of A-δ fibers.Journal of anesthesia · 2023Article
- A novel thermoelectric device integrated with a psychophysical paradigm to study pain processing in human subjects.Journal of neuroscience methods · 2023Article
- [Pain and epilepsy : A clinical, neuroanatomical and pathophysiological review].Schmerz (Berlin, Germany) · 2018Article
- Evidence-based source modeling of nociceptive cortical responses: A direct comparison of scalp and intracranial activity in humans.Human brain mapping · 2017Article
- The Frontal Area with Higher Frequency Response Is the Principal Feature of Laser-Evoked Potentials in Rats with Chronic Inflammatory Pain: A Parallel Factor Analysis Study.Frontiers in neurology · 2017Article
- The primary somatosensory cortex and the insula contribute differently to the processing of transient and sustained nociceptive and non-nociceptive somatosensory inputs.Human brain mapping · 2015Article
- Invariance in current dipole moment density across brain structures and species: physiological constraint for neuroimaging.NeuroImage · 2015Article
- Painful cutaneous laser stimuli induce event-related gamma-band activity in the lateral thalamus of humans.Journal of neurophysiology · 2015Article
- Electrophysiological correlates of the BOLD signal for EEG-informed fMRI.Human brain mapping · 2015Review
- EEG frequency tagging to dissociate the cortical responses to nociceptive and nonnociceptive stimuli.Journal of cognitive neuroscience · 2014Article
- Cortical representation of pain in primary sensory-motor areas (S1/M1)--a study using intracortical recordings in humans.Human brain mapping · 2013Article
- Emotional modulation of experimental pain: a source imaging study of laser evoked potentials.Frontiers in human neuroscience · 2013Article
- Article
- Distinct Somatic Discrimination Reflected by Laser-Evoked Potentials Using Scalp EEG Leads.Journal of medical and biological engineeringArticle
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
The cortical potentials evoked by cutaneous application of a laser stimulus (laser evoked potentials, LEP) often include potentials in the primary somatic sensory cortex (S1), which may be located within the subdivisions of S1 including Brodmann areas 3A, 3B, 1, and 2. The precise location of the LEP generator may clarify the pattern of activation of human S1 by painful stimuli. We now test the hypothesis that the generators of the LEP are located in human Brodmann area 1 or 3A within S1. Local field potential (LFP) source analysis of the LEP was obtained from subdural grids over sensorimotor cortex in two patients undergoing epilepsy surgery. The relationship of LEP dipoles was compared with dipoles for somatic sensory potentials evoked by median nerve stimulation (SEP) and recorded in area 3B (see Baumgärtner U, Vogel H, Ohara S, Treede RD, Lenz FA. J Neurophysiol 104: 3029-3041, 2010). Both patients had an early radial dipole in S1. The LEP dipole was located medial, anterior, and deep to the SEP dipole, which suggests a nociceptive dipole in area 3A. One patient had a later tangential dipole with positivity posterior, which is opposite to the orientation of the SEP dipole in area 3B. The reversal of orientations between modalities is consistent with the cortical surface negative orientation resulting from superficial termination of thalamocortical neurons that receive inputs from the spinothalamic tract. Therefore, the present results suggest that the LEP may result in a radial dipole consistent with a generator in area 3A and a putative later tangential generator in area 3B.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.