Trial reportThe Journal of nutrition2011
Placental expression of the heme transporter, feline leukemia virus subgroup C receptor, is related to maternal iron status in pregnant adolescents.
Trial report in The Journal of nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Placental iron transport under maternal stress: a missing link in foetal programming and mental health.EBioMedicine · 2026Article
- Placental ferroportin protein abundance is associated with neonatal erythropoietic activity and iron status in newborns at high risk for iron deficiency and anemia.The American journal of clinical nutrition · 2024Article
- Placental Erythroferrone and Erythropoietin mRNA Expression is not Associated with Maternal or Neonatal Iron Status in Adolescents Carrying Singletons and Adult Women Carrying Multiples.The Journal of nutrition · 2023Article
- Iron Metabolism and Ferroptosis in Physiological and Pathological Pregnancy.International journal of molecular sciences · 2022Review
- Review
- Transporter Regulation in Critical Protective Barriers: Focus on Brain and Placenta.Pharmaceutics · 2022Review
- Fetal iron uptake from recent maternal diet and the maternal RBC iron pool.The American journal of clinical nutrition · 2022Article
- The ferroptosis and iron-metabolism signature robustly predicts clinical diagnosis, prognosis and immune microenvironment for hepatocellular carcinoma.Cell communication and signaling : CCS · 2020Article
- Effect of Oral Supplementation of Healthy Pregnant Sows with Sucrosomial Ferric Pyrophosphate on Maternal Iron Status and Hepatic Iron Stores in Newborn Piglets.Animals : an open access journal from MDPI · 2020Article
- Iron homeostasis during pregnancy.The American journal of clinical nutrition · 2017Review
- Maternal iron status during pregnancy compared with neonatal iron status better predicts placental iron transporter expression in humans.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Vitamin D status is inversely associated with anemia and serum erythropoietin during pregnancy.The American journal of clinical nutrition · 2015Article
- Maternal diet but not gestational weight gain predicts central adiposity accretion in utero among pregnant adolescents.International journal of obesity (2005) · 2015Article
- Gestational iron deficiency is associated with pica behaviors in adolescents.The Journal of nutrition · 2014Observational
- Placental heme receptor LRP1 correlates with the heme exporter FLVCR1 and neonatal iron status.Reproduction (Cambridge, England) · 2014Article
- Placental CYP27B1 and CYP24A1 expression in human placental tissue and their association with maternal and neonatal calcitropic hormones.The Journal of clinical endocrinology and metabolism · 2014Article
- Iron overload in Plasmodium berghei-infected placenta as a pathogenesis mechanism of fetal death.Frontiers in pharmacology · 2014Article
- Molecular insights into the regulation of iron metabolism during the prenatal and early postnatal periods.Cellular and molecular life sciences : CMLS · 2013Review
- Maternal hepcidin is associated with placental transfer of iron derived from dietary heme and nonheme sources.The Journal of nutrition · 2012Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Little is known about the expression of heme transporters in human placenta and possible associations between these transporters and maternal or neonatal iron status. To address this area of research, relative protein expression of 2 heme transporters, Feline Leukemia Virus, Subgroup C, Receptor 1 (FLVCR1) and Breast Cancer Resistance Protein (BCRP), was assessed using Western-blot analysis in human placental tissue in relation to maternal/neonatal iron status and placental iron concentration. Placental FLVCR1 (n = 71) and BCRP (n = 83) expression were assessed at term (36.6-41.7 wk gestation) in a cohort of pregnant adolescents (13-18 y of age) at high-risk of iron deficiency. Both FLVCR1 and BCRP were detected in all placental samples assayed. Placental FLVCR1 expression was positively related to placental BCRP expression (n = 69; R(2) = 0.104; P < 0.05). Adolescents that were anemic at delivery had lower placental FLVCR1 expression (n = 49; P < 0.05). Placental FLVCR1 expression was positively associated with placental iron concentration at delivery (n = 61; R(2) = 0.064; P < 0.05). In contrast, placental BCRP expression was not significantly associated with maternal iron status or placental iron content. Both FLVCR1 and BCRP are highly expressed in human placental tissue, but only FLVCR1 was significantly inversely associated with maternal iron status and placental iron concentration. Further analysis is needed to explore potential functional roles of FLVCR1 in human placental iron transport.
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