ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Calcium/calmodulin-dependent protein kinase II mediates group I metabotropic glutamate receptor-dependent protein synthesis and long-term depression in rat hippocampus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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65 citing papers in PubMed, 108 citations in OpenAlex.
- [Correlations of calmodulin and neurotransmitters with polysomnographic parameters in patients with chronic insomnia disorder].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
- Activity drives local CaMKII synthesis and subcellular localization via autophosphorylation-dependent pathways.bioRxiv : the preprint server for biology · 2025Article
- Mineral Homeostasis and Depression: Implications for Prevention and Therapeutic Support-A Narrative Review.International journal of molecular sciences · 2025Review
- Early life seizures chronically disrupt L-type voltage gated calcium channel regulation of mGluR mediated long term depression via interactions with protein phosphatase 2A.Neurobiology of disease · 2025Article
- A revised view of the role of CaMKII in learning and memory.Nature neuroscience · 2025Review
- CaMKII modulates memory destabilization by regulating the interaction of theta and gamma oscillations.Frontiers in cellular neuroscience · 2025Article
- Relationship between emotional eating and nutritional intake in adult women with overweight and obesity: a cross-sectional study.Nutrition journal · 2024Article
- Alpha-secretase inhibition impairs Group I metabotropic glutamate receptor-mediated protein synthesis, long-term potentiation and long-term depression.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Hippocampal CaMKII inhibition induces reactivation-dependent amnesia for extinction memory and causes fear relapse.Scientific reports · 2023Article
- Review
- Mechanisms of mGluR-dependent plasticity in hippocampal area CA2.Hippocampus · 2023Article
- Arc ubiquitination regulates endoplasmic reticulum-mediated CaFrontiers in cellular neuroscience · 2023Article
- Association between dietary calcium and depression among American adults: National health and nutrition examination survey.Frontiers in nutrition · 2023Article
- A Novel CaMKII Inhibitory Peptide Blocks Relapse to Morphine Seeking by Influencing Synaptic Plasticity in the Nucleus Accumbens Shell.Brain sciences · 2022Article
- Bidirectional regulation of synaptic SUMOylation by Group 1 metabotropic glutamate receptors.Cellular and molecular life sciences : CMLS · 2022Article
- Mitochondrial Biogenesis in Neurons: How and Where.International journal of molecular sciences · 2021Review
- Disruption of brain conductivity and permittivity and neurotransmitters induced by citrate-coated silver nanoparticles in male rats.Environmental science and pollution research international · 2021Article
- Differential regulation of local mRNA dynamics and translation following long-term potentiation and depression.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Effects of extracellular vesicles from mesenchymal stem cells on oxygen-glucose deprivation/reperfusion-induced neuronal injury.World journal of emergency medicine · 2021Article
- Phosphorylation of the Retinal Ribbon Synapse Specific t-SNARE Protein Syntaxin3B Is Regulated by Light via a CaFrontiers in cellular neuroscience · 2020Article
5 more citing papers are in PubMed but not listed here.
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6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activation of Group I metabotropic glutamate receptors (mGluRs) in rat hippocampus induces a form of long-term depression (LTD) that is dependent on protein synthesis. However, the intracellular mechanisms leading to the initiation of protein synthesis and expression of LTD after mGluR activation are only partially understood. We investigated the role of several pathways linked to mGluR activation, translation initiation, and induction of LTD. We found that Group I mGluR-dependent protein synthesis and associated LTD, as induced by the agonist (RS)-3,5-dihydrophenylglycine (DHPG) or paired-pulse synaptic stimulation, was dependent on activation of calcium/calmodulin-dependent protein kinase IIα (CaMKII). DHPG induced a transient increase in the level of phospho-CaMKII (phospho-CaMKII(T286)) in synaptoneurosomes prepared from whole hippocampus and in CA1 minislices. In synaptoneurosomes, DHPG also induced an increase in phosphorylation of eIF4E, and an increase in protein synthesis that was abolished by translation inhibitors and the CaMKII inhibitors 1-[N,O-bis(5-isoquinolinesulphonyl)-N-methyl-l-tyrosyl]-4-phenylpiperazine (KN62) and 2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)amino-N-(4-chloro-cinnamyl)-N-methylbenzylamine (KN93). In field recordings from CA1, both the translation inhibitor cycloheximide and KN62 significantly reduced DHPG-induced LTD. Combined application did not further reduce the LTD, suggesting a common mechanism. In whole-cell recordings, a third CaMKII inhibitor, AIP (autocamtide-2-related inhibitory peptide), significantly reduced the DHPG-induced LTD of synaptic currents. Inhibition of the classical pathway mediating many Group I mGluR effects by blocking PKC (protein kinase C) or PLC (phospholipase C) did not impair DHPG-induced protein synthesis or LTD. Collectively, these findings demonstrate an important role for CaMKII in mediating the initiation of protein synthesis that then supports the postsynaptic expression of DHPG-induced LTD.
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