ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Olfactory trace conditioning in Drosophila.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 55 citations in OpenAlex.
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- Prediction error drives associative learning and conditioned behavior in a spiking model of Drosophila larva.iScience · 2024Article
- Neural manifolds for odor-driven innate and acquired appetitive preferences.Nature communications · 2023Article
- Local 5-HT signaling bi-directionally regulates the coincidence time window for associative learning.Neuron · 2023Article
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- The Role of Dopamine in Associative Learning in Drosophila: An Updated Unified Model.Neuroscience bulletin · 2021Review
- Predictive olfactory learning in Drosophila.Scientific reports · 2021Article
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- Recurrent loops: Incorporating prediction error and semantic/episodic theories into Drosophila associative memory models.Genes, brain, and behavior · 2019Review
- How Swift Is Cry-Mediated Magnetoreception? Conditioning in an American Cockroach Shows Sub-second Response.Frontiers in behavioral neuroscience · 2018Article
- Calcium in Kenyon Cell Somata as a Substrate for an Olfactory Sensory Memory inFrontiers in cellular neuroscience · 2018Article
- Trace Conditioning inFrontiers in neural circuits · 2017Article
- Genetic Dissection of Aversive Associative Olfactory Learning and Memory in Drosophila Larvae.PLoS genetics · 2016Article
- Reversing Stimulus Timing in Visual Conditioning Leads to Memories with Opposite Valence in Drosophila.PloS one · 2015Article
- Differential associative training enhances olfactory acuity in Drosophila melanogaster.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Temporal features of spike trains in the moth antennal lobe revealed by a comparative time-frequency analysis.PloS one · 2014Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neural representation of a sensory stimulus evolves with time, and animals keep that representation even after stimulus cessation (i.e., a stimulus "trace"). To contrast the memories of an odor and an odor trace, we here establish a rigorous trace conditioning paradigm in the fruit fly, Drosophila melanogaster. We modify the olfactory associative learning paradigm, in which the odor and electric shock are presented with a temporal overlap (delay conditioning). Given a few-second temporal gap between the presentations of the odor and the shock in trace conditioning, the odor trace must be kept until the arrival of electric shock to form associative memory. We found that memories after trace and delay conditioning have striking similarities: both reached the same asymptotic learning level, although at different rates, and both kinds of memory have similar decay kinetics and highly correlated generalization profiles across odors. In search of the physiological correlate of the odor trace, we used in vivo calcium imaging to characterize the odor-evoked activity of the olfactory receptor neurons in the antennal lobe. After the offset of odor presentation, the receptor neurons showed persistent, odor-specific response patterns that lasted for a few seconds and were fundamentally different from the response patterns during the stimulation. Weak correlation between the behavioral odor generalization profile in trace conditioning and the physiological odor similarity profiles in the antennal lobe suggest that the odor trace used for associative learning may be encoded downstream of the olfactory receptor neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.