ArticleJournal of clinical microbiology2011
Rapid detection and molecular differentiation of toxigenic Corynebacterium diphtheriae and Corynebacterium ulcerans strains by LightCycler PCR.
Article in Journal of clinical microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 45 citations in OpenAlex.
- Emerging Corynebacterium diphtheriae ST-212 cluster with truncated tox gene linked by possible sexual transmission.Infection · 2026Article
- Comprehensive Study of Some Cyanobacteria in Moscow Waterbodies (Russia), Including Characteristics of the ToxigenicToxins · 2025Article
- Review: Known, Emerging, and Remerging Pharyngitis Pathogens.The Journal of infectious diseases · 2024Review
- Challenges of Diphtheria Toxin Detection.Toxins · 2024Review
- Epitope Mapping of the Diphtheria Toxin and Development of an ELISA-Specific Diagnostic Assay.Vaccines · 2021Article
- Detection and Characterization of Diphtheria Toxin Gene-BearingJournal of clinical microbiology · 2020Article
- Article
- Diphtheria Outbreak in Amerindian Communities, Wonken, Venezuela, 2016-2017.Emerging infectious diseases · 2018Article
- The detection of toxigenic Corynebacterium ulcerans from cats with nasal inflammation in Japan.Epidemiology and infection · 2015Article
- Outbreak with clonally related isolates of Corynebacterium ulcerans in a group of water rats.BMC microbiology · 2015Article
- Corynebacterium urealyticum: a comprehensive review of an understated organism.Infection and drug resistance · 2015Review
- Nontoxigenic tox-bearing Corynebacterium ulcerans infection among game animals, Germany.Emerging infectious diseases · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The systemic symptoms of diphtheria are caused by the tox-encoded diphtheria toxin (DT) which is produced by toxigenic Corynebacterium spp. Besides the classical agent C. diphtheriae, the zoonotic pathogen C. ulcerans has increasingly been reported as an emerging pathogen for diphtheria. The reliable detection of toxigenic Corynebacterium spp. is of substantial importance for both diphtheria surveillance in the public health sector and the clinical workup of a patient with diphtherialike symptoms. Since the respective tox genes of C. diphtheriae and C. ulcerans differ from each other in both DNA and amino acid sequence, both tox genes should be covered by novel real-time PCR methods. We describe the development and validation of a LightCycler PCR assay which reliably recognizes tox genes from both C. diphtheriae and C. ulcerans and differentiates the respective target genes by fluorescence resonance energy transfer (FRET) hybridization probe melting curve analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.