Evidence map›Paper›PMID 21593047›Full record

ArticleMolecular biology and evolution2011

A cell-molecular approach predicts vertebrate evolution.

John Steven Torday, Virender Kumar Rehan

Abstract read
In one paragraph

Article in Molecular biology and evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Life is determined by its environment.International journal of astrobiology · 2016
    Article
  3. Article
  4. Article
  5. Maternal/neonatal vitamin D deficiency: a risk factor for bronchopulmonary dysplasia in preterms?Journal of perinatology : official journal of the California Perinatal Association · 2015
    Article
  6. Article
  7. A central theory of biology.Medical hypotheses · 2015
    Article
  8. Review
  9. Evolution and Cell Physiology. 1. Cell signaling is all of biology.American journal of physiology. Cell physiology · 2013
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. On the evolution of development.Trends in developmental biology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

John Steven TordayDepartment of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA. jtorday@labiomed.org
Virender Kumar Rehan

Funding

HORMONAL REGULATION OF LUNG DEVELOPMENT;PTHrP BIOLOGYR01HL055268 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI TORDAY, JOHN STEVEN · 1997 to 2009
$3.3M
PPARgamma Signaling/Lung Fibroblast TransdifferentiationR01HL075405 · NHLBI · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI REHAN, VIRENDER K · 2005 to 2009
$1.7M
Fibroblast Cell Signaling in Utero Nicotine-Induced Lung InjuryR01HD051857 · NICHD · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI REHAN, VIRENDER K · 2008 to 2012
$1.7M
A Molecular Approach to Prevent Pulmonary Dysfunction in the Intrauterine GrowthR03HD058948 · NICHD · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI REHAN, VIRENDER K · 2009 to 2010
$137k
NHLBI NIH HHS HL-075405NHLBI NIH HHS HL-55268NHLBI NIH HHS R01 HL055268NHLBI NIH HHS R01 HL075405NICHD NIH HHS HD-051857NICHD NIH HHS HD058948NICHD NIH HHS R01 HD051857NICHD NIH HHS R03 HD058948
6 · The paper itself

Abstract

In contrast to the conventional use of genes to determine the evolution of phenotypes, we have functionally integrated epithelial-mesenchymal interactions that have facilitated lung phylogeny and ontogeny in response to major geologic epochs. As such, this model reveals the underlying principles of lung physiology based on the evolutionary interactions between internal and external selection pressures, providing a novel understanding of lung biology. As a result, it predicts how cell-molecular changes in this process can cause disease and offers counterintuitive insights to diagnosis and treatment based on evolutionary principles.

Indexed as

Biological EvolutionModels, BiologicalPhylogenySelection, GeneticAnimalsCollagen Type IVGenes, RegulatorLungPulmonary AlveoliVertebratesCollagen Type IV

Identifiers

PMID21593047
PMCPMC3199438

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.