ArticleJournal of the Royal Society, Interface2011
Modelling platelet-blood flow interaction using the subcellular element Langevin method.
Article in Journal of the Royal Society, Interface, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Reconstructing single-cell resolution from spatial transcriptomics with CellRefiner.Nature communications · 2026Article
- Platelet Biorheology and Mechanobiology in Thrombosis and Hemostasis: Perspectives from Multiscale Computation.International journal of molecular sciences · 2024Review
- Balancing competing effects of tissue growth and cytoskeletal regulation during Drosophila wing disc development.Nature communications · 2024Article
- Investigating clot-flow interactions by integrating intravital imaging with in silico modeling for analysis of flow, transport, and hemodynamic forces.Scientific reports · 2024Article
- SEMAPL bioengineering · 2023Article
- Combined computational modeling and experimental analysis integrating chemical and mechanical signals suggests possible mechanism of shoot meristem maintenance.PLoS computational biology · 2022Article
- In Vitro Measurements of Shear-Mediated Platelet Adhesion Kinematics as Analyzed through Machine Learning.Annals of biomedical engineering · 2021Article
- Predictive modelling of thrombus formation in diabetic retinal microaneurysms.Royal Society open science · 2020Article
- Quantifying Platelet Margination in Diabetic Blood Flow.Biophysical journal · 2018Article
- Multiscale simulation of thrombus growth and vessel occlusion triggered by collagen/tissue factor using a data-driven model of combinatorial platelet signalling.Mathematical medicine and biology : a journal of the IMA · 2017Article
- Mechanocellular models of epithelial morphogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Multi-scale computational study of the mechanical regulation of cell mitotic rounding in epithelia.PLoS computational biology · 2017Article
- Reversals and collisions optimize protein exchange in bacterial swarms.Physical review. E · 2017Article
- Modelling of platelet-fibrin clot formation in flow with a DPD-PDE method.Journal of mathematical biology · 2016Article
- Multicomponent model of deformation and detachment of a biofilm under fluid flow.Journal of the Royal Society, Interface · 2015Article
- A Multiple Time Stepping Algorithm for Efficient Multiscale Modeling of Platelets Flowing in Blood Plasma.Journal of computational physics · 2015Article
- A phenomenological particle-based platelet model for simulating filopodia formation during early activation.International journal for numerical methods in biomedical engineering · 2015Article
- Multiscale Particle-Based Modeling of Flowing Platelets in Blood Plasma Using Dissipative Particle Dynamics and Coarse Grained Molecular Dynamics.Cellular and molecular bioengineering · 2014Article
- Computational modelling of epidermal stratification highlights the importance of asymmetric cell division for predictable and robust layer formation.Journal of the Royal Society, Interface · 2014Article
- Three-dimensional multi-scale model of deformable platelets adhesion to vessel wall in blood flow.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
In this paper, a new three-dimensional modelling approach is described for studying fluid-viscoelastic cell interaction, the subcellular element Langevin (SCEL) method, with cells modelled by subcellular elements (SCEs) and SCE cells coupled with fluid flow and substrate models by using the Langevin equation. It is demonstrated that: (i) the new method is computationally efficient, scaling as (N) for N SCEs; (ii) cell geometry, stiffness and adhesivity can be modelled by directly relating parameters to experimentally measured values; (iii) modelling the fluid-platelet interface as a surface leads to a very good correlation with experimentally observed platelet flow interactions. Using this method, the three-dimensional motion of a viscoelastic platelet in a shear blood flow was simulated and compared with experiments on tracking platelets in a blood chamber. It is shown that the complex platelet-flipping dynamics under linear shear flows can be accurately recovered with the SCEL model when compared with the experiments. All experimental details and electronic supplementary material are archived at http://biomath.math.nd.edu/scelsupplementaryinformation/.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.