ArticleThe Journal of infectious diseases2011
Human leukocyte antigen genotypes in the genetic control of adaptive immune responses to smallpox vaccine.
Article in The Journal of infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Genetic polymorphisms associated with rubella virus-specific cellular immunity following MMR vaccination.Human genetics · 2014Pooled it
- HLA Variation and SARS-CoV-2 Specific Antibody Response.Viruses · 2023Review
- Pilot genome-wide association study of antibody response to inactivated SARS-CoV-2 vaccines.Frontiers in immunology · 2022Article
- Article
- A large population-based association study between HLA and KIR genotypes and measles vaccine antibody responses.PloS one · 2017Article
- A time transect of exomes from a Native American population before and after European contact.Nature communications · 2016Article
- Systems vaccinology: Enabling rational vaccine design with systems biological approaches.Vaccine · 2015Review
- Fine Mapping Causal Variants with an Approximate Bayesian Method Using Marginal Test Statistics.Genetics · 2015Article
- HLA alleles associated with the adaptive immune response to smallpox vaccine: a replication study.Human genetics · 2014Article
- Article
- High-throughput assay optimization and statistical interpolation of rubella-specific neutralizing antibody titers.Clinical and vaccine immunology : CVI · 2014Article
- Characterization of humoral and cellular immunity to rubella vaccine in four distinct cohorts.Immunologic research · 2014Article
- Cytokine production associated with smallpox vaccine responses.Immunotherapy · 2014Review
- Genetic variants within the MHC region are associated with immune responsiveness to childhood vaccinations.Vaccine · 2013Article
- Genetic variation in IL18R1 and IL18 genes and Inteferon γ ELISPOT response to smallpox vaccination: an unexpected relationship.The Journal of infectious diseases · 2013Article
- Soft truncation thresholding for gene set analysis of RNA-seq data: application to a vaccine study.Scientific reports · 2013Article
- Race and sex-based differences in cytokine immune responses to smallpox vaccine in healthy individuals.Human immunology · 2013Article
- Vaccinomics, adversomics, and the immune response network theory: individualized vaccinology in the 21st century.Seminars in immunology · 2013Review
- High-dimensional gene expression profiling studies in high and low responders to primary smallpox vaccination.The Journal of infectious diseases · 2012Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of human leukocyte antigen (HLA) genes in mediating adaptive immune responses to smallpox vaccine remains unknown.
methodsWe determined genotypes for a group of individuals (n = 1071) who received a single dose of smallpox vaccine (Dryvax, Wyeth Laboratories) and examined associations between HLA alleles and 15 immune outcomes to smallpox vaccine on a per-locus and a per-allele level.
resultsWe found significant associations between the HLA-B and HLA - DQB1 loci and vaccinia-induced antibodies (P = .04 for each locus), with the HLA-B*1302 (P = .036), B*3802 (P = .011), DQB1*0302 (P = .015), and DQB1*0604 (P = .017) alleles being associated with higher levels. Significant global associations were identified between vaccinia-specific interferon (IFN)-γ and DQA1 (P = .003), interleukin (IL)-1β and HLA-B (P = .004), tumor necrosis factor (TNF)-α and HLA-B (P = .006), and IL-6 and HLA-B locus (P = .016) for secreted cytokines, as well as between CD8α(+) IFN-γ Elispot responses and DQB1 (P = .027). Subjects carrying B*3906 (P = .006) and B*5701 (P < .001) secreted higher levels of IL-1β than did subjects who did not carry these alleles. Subjects carrying the B*5301 (P = .047) and B*5601 (P = .008) alleles secreted less IL-1β, compared with subjects who did not carry these alleles. The B*3502 (P = .009), B*5601 (P = .004), and B*5701 (P < .001) alleles were significantly associated with variations in TNF-α secretion.
conclusionsThese data suggest that variations in antibody and cellular IFN-γ, IL-1β, TNF-α, and IL-6 immune responses after receipt of smallpox vaccine are genetically controlled by HLA genes or genes in close linkage disequilibrium to these alleles.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.