Evidence map›Paper›PMID 21592771›Full record

ReviewCurrent opinion in biotechnology2011

Glycosyltransferase structural biology and its role in the design of catalysts for glycosylation.

Aram Chang, Shanteri Singh, George N Phillips, Jon S Thorson

Abstract readReview
In one paragraph

Review in Current opinion in biotechnology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed.

  1. Article
  2. Article
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  6. Article
  7. The metabolic enzyme GYS1 condenses with NONO/p54Cell death and differentiation · 2025
    Article
  8. Article
  9. Genome-Wide Identification of UGT Gene Family and Functional Analysis ofInternational journal of molecular sciences · 2025
    Article
  10. Article
  11. Re-evaluation of theBiochemistry · 2025
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Aram ChangDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Shanteri Singh
George N Phillips
Jon S Thorson

Funding

Specialized Center for Eukaryotic Structural GenomicsU54GM074901 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI MARKLEY, JOHN LUTE · 2005 to 2009
$18.9M
In Vitro Glycorandomization of Natural ProductsR37AI052218 · NIAID · UNIVERSITY OF KENTUCKY · PI THORSON, JON SCOTT · 2012 to 2021
$4.0M
In Vitro Glycorandomization of Natural ProductsR01AI052218 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI THORSON, JON SCOTT · 2002 to 2011
$3.8M
STUDIES ON CALICHEAMICIN BIOSYNTHESIS AND SELF RESISTANCER01CA084374 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI THORSON, JON SCOTT · 2000 to 2013
$3.6M
Enzyme Discovery for Natural Product BiosynthesisU01GM098248 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI PHILLIPS, GEORGE NEAL · 2011 to 2015
$2.8M
NCI NIH HHS CA84374NCI NIH HHS R01 CA084374NIAID NIH HHS AI52218NIAID NIH HHS R01 AI052218NIAID NIH HHS R37 AI052218NIGMS NIH HHS GM074901NIGMS NIH HHS U01 GM098248NIGMS NIH HHS U54 GM074901
6 · The paper itself

Abstract

Glycosyltransferases (GTs) are ubiquitous in nature and are required for the transfer of sugars to a variety of important biomolecules. This essential enzyme family has been a focus of attention from both the perspective of a potential drug target and a catalyst for the development of vaccines, biopharmaceuticals and small molecule therapeutics. This review attempts to consolidate the emerging lessons from Leloir (nucleotide-dependent) GT structural biology studies and recent applications of these fundamentals toward rational engineering of glycosylation catalysts.

Indexed as

BiotechnologyCarbohydratesCatalysisGlycosylationGlycosyltransferasesNucleotidesProtein EngineeringProtein FoldingCarbohydratesGlycosyltransferasesNucleotides

Identifiers

PMID21592771
PMCPMC3163058

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.