Trial reportDrug and alcohol dependence2011
Poor response to sertraline in methamphetamine dependence is associated with sustained craving for methamphetamine.
Trial report in Drug and alcohol dependence, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Canadian guideline for the clinical management of high-risk drinking and alcohol use disorder.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2023Guideline
- Selective serotonin reuptake inhibitors in the treatment of depression, anxiety, and post-traumatic stress disorder in substance use disorders: a Bayesian meta-analysis.European journal of clinical pharmacology · 2022Pooled it
- Cocaine craving and use during pharmacotherapy trials for cocaine use disorder: A multi-trajectory analysis.Drug and alcohol dependence · 2025Trial
- Craving among individuals with stimulant use disorder in residential social model-based treatment - Can exercise help?Drug and alcohol dependence · 2022Trial
- Association between venlafaxine use and the risk of withdrawal from nonopioid substances: a nationwide, population-based study.Harm reduction journal · 2026Article
- Rethinking trazodone for insomnia in alcohol use disorder.Addiction science & clinical practice · 2025Article
- Using illicit drugs alone in Vancouver, Canada: a gender-based analysis.Substance abuse treatment, prevention, and policy · 2025Article
- Trajectories of craving in the course of pharmacotherapy trials for methamphetamine use disorder.Addiction (Abingdon, England) · 2024Article
- Article
- Pharmacological Treatments for Methamphetamine Use Disorder: Current Status and Future Targets.Substance abuse and rehabilitation · 2024Review
- Narcotics Anonymous members in recovery from methamphetamine use disorder.The American journal on addictions · 2023Article
- Psychosocial and pharmacologic interventions for problematic methamphetamine use: Findings from a scoping review of the literature.PloS one · 2023Article
- β-caryophyllene, an FDA-Approved Food Additive, Inhibits Methamphetamine-Taking and Methamphetamine-Seeking Behaviors PossiblyFrontiers in pharmacology · 2021Article
- Drug-Induced Craving for Methamphetamine Is Associated With Neural Methamphetamine Cue Reactivity.Journal of studies on alcohol and drugs · 2019Article
- N-Acetyl and Glutamatergic Neurometabolites in Perisylvian Brain Regions of Methamphetamine Users.The international journal of neuropsychopharmacology · 2019Article
- Effect of Abstinence on Depression, Anxiety, and Quality of Life in Chronic Methamphetamine Users in a Therapeutic Community.International journal of high risk behaviors & addiction · 2015Article
- A naturalistic study of the association between antidepressant treatment and outcome of smoking cessation treatment.The Journal of clinical psychiatry · 2014Observational
- Glutamatergic neurometabolites during early abstinence from chronic methamphetamine abuse.The international journal of neuropsychopharmacology · 2014Article
- Methamphetamine: an update on epidemiology, pharmacology, clinical phenomenology, and treatment literature.Drug and alcohol dependence · 2014Review
- An evaluation of the evidence that methamphetamine abuse causes cognitive decline in humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDepression is common among individuals with methamphetamine (MA) use disorders. As agents that enhance serotonergic function are frequently used to treat depression, one might predict that they would be useful medications for MA dependence. However, clinical trials of serotonergic agents for MA addiction have been unsuccessful.
objectiveTo identify factors that distinguish MA-dependent research participants who increased MA self-administration while receiving treatment with the selective serotonin reuptake inhibitor (SSRI) sertraline from other groups of participants.
methodUsing a dataset from a 12-week randomized, placebo-controlled trial of sertraline (100mg daily) for MA addiction, we identified participants who had completed at least 8 weeks of the trial (n=61 sertraline, n=68 placebo). We compared the proportions of MA-positive urine tests for weeks 8-12 of the trial for these subjects to their pre-randomization baseline, and identified those subjects who increased MA use during treatment. Using classification trees, we then assessed all data collected during the study to identify factors associated with increasing MA use during treatment with sertraline, compared to placebo.
resultsMore subjects in the sertraline condition increased MA use during treatment (n=13) than in the placebo condition (n=5; p=0.03). Classification trees identified multiple factors from both pre-treatment and in-treatment data that were associated with increased MA use during treatment. Only elevated in-treatment craving for MA specifically characterized subjects in the sertraline group who increased their MA use.
conclusionsSome MA-abusing individuals treated with SSRIs have sustained craving with an increased propensity to relapse during treatment despite psychosocial treatment interventions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.