ArticleJournal of gastroenterology and hepatology2011
Prevalence of two homologous genes encoding glycosyltransferases of Helicobacter pylori in the United States and Japan.
Article in Journal of gastroenterology and hepatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Nepalese Helicobacter pylori Genotypes Reflects a Geographical Diversity than a True Virulence FactorAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Article
- Effect of miR-340 on gastric cancer cell proliferation and apoptosis.International journal of clinical and experimental pathology · 2015Article
- Helicobacter pylori virulence genes in the five largest islands of Indonesia.Gut pathogens · 2015Article
- The Prevalence of Helicobacter pylori Virulence Factors in Bhutan, Vietnam, and Myanmar Is Related to Gastric Cancer Incidence.BioMed research international · 2015Article
- Virulence genes of Helicobacter pylori in the Dominican Republic.Journal of medical microbiology · 2014Article
- Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
aimjhp0562 and β-(1,3)galT (jhp0563) of Helicobacter pylori have been suggested as novel virulent factors; however, the clinical associations and functions of these genes remain unclear. We examined the prevalence of jhp0562, β-(1,3)galT, and cagA in the United States (US) and Japanese populations.
methodsA total of 308 strains (171 from the US and 137 from Japan) were examined for the status of jhp0562, β-(1,3)galT, and cagA by polymerase chain reaction.
resultsThere were significant differences in the status of jhp0562, β-(1,3)galT and cagA between the US and Japanese populations (P < 0.001). In the US, the prevalence of β-(1,3)galT was significantly lower in strains isolated from patients with duodenal ulcer (DU) or gastric ulcer (GU) than those with gastritis (47.8% and 32.1% vs 72.0%, P < 0.01), and the absence of β-(1,3)galT was an independent factor discriminating DU and GU from gastritis (adjusted odds ratios, 4.21 and 8.52; 95% confidence intervals, 1.75 to 10.12 and 2.76 to 26.33, respectively). In the US, the prevalence of the jhp0562-positive/β-(1,3)galT-negative genotype was significantly higher in strains from DU and GU patients than in those from gastritis patients (50.0%, 67.9%, and 24.4%, P < 0.01) and the cagA status was significantly correlated with that of jhp0562 and inversely correlated with that of β-(1,3)galT. In contrast, the prevalence of these three genes was not significantly different in Japan.
conclusionsjhp0562 or β-(1,3)galT can be used to discriminate peptic ulcers from gastritis in the US, but not in Japan.
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