ArticleAnnals of human genetics2011
Diversification of the ADH1B gene during expansion of modern humans.
Article in Annals of human genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Ancient Yellow River ancestry and divergent admixture histories in the Qiang people.Science advances · 2026Article
- Genetic history of Scythia.Science advances · 2025Article
- Contribution of infectious diseases to the selection of ADH1B and ALDH2 gene variants in Asian populations.Alcohol, clinical & experimental research · 2024Article
- The STROMICS genome study: deep whole-genome sequencing and analysis of 10K Chinese patients with ischemic stroke reveal complex genetic and phenotypic interplay.Cell discovery · 2023Article
- The Promise of an Evolutionary Perspective of Alcohol Consumption.Neuroscience insights · 2023Review
- Signatures of Convergent Evolution and Natural Selection at the Alcohol Dehydrogenase Gene Region are Correlated with Agriculture in Ethnically Diverse Africans.Molecular biology and evolution · 2022Article
- Genomic Insights Into the Genetic Structure and Natural Selection of Mongolians.Frontiers in genetics · 2021Article
- Article
- Genome-wide association study of alcohol dependence in male Han Chinese and cross-ethnic polygenic risk score comparison.Translational psychiatry · 2019Article
- A Comprehensive Map of Genetic Variation in the World's Largest Ethnic Group-Han Chinese.Molecular biology and evolution · 2018Article
- Recent Selection on a Class I ADH Locus Distinguishes Southwest Asian Populations Including Ashkenazi Jews.Genes · 2018Article
- Detecting past and ongoing natural selection among ethnically Tibetan women at high altitude in Nepal.PLoS genetics · 2018Article
- Distinct Prognostic Values of Alcohol Dehydrogenase Family Members for Non-Small Cell Lung Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- ADH1B: From alcoholism, natural selection, and cancer to the human phenome.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2018Review
- Was ADH1B under Selection in European Populations?American journal of human genetics · 2016Article
- Fast Principal-Component Analysis Reveals Convergent Evolution of ADH1B in Europe and East Asia.American journal of human genetics · 2016Article
- Deep History of East Asian Populations Revealed Through Genetic Analysis of the Ainu.Genetics · 2016Article
- Dissecting ancestry genomic background in substance dependence genome-wide association studies.Pharmacogenomics · 2015Article
- Fetal alcohol spectrum disorders and their transmission through genetic and epigenetic mechanisms.Frontiers in genetics · 2014Review
- High diversity and no significant selection signal of human ADH1B gene in Tibet.Investigative genetics · 2012Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
A variant allele, ADH1B*48His, also known as ADH1B*2, at the human Alcohol Dehydrogenase 1B gene (ADH1B) is strongly associated with alcoholism in some populations and has an unusual geographic distribution. Strong evidence implies selection has increased the frequency of this allele in some East Asian populations but does not fully explain its geographic pattern. We have studied haplotypes of 10 single nucleotide polymorphisms (SNPs) and two short tandem repeat polymorphisms (STRPs) in the ADH1B region in 2,206 individuals from a worldwide set of populations. These SNPs and STRPs define nine common haplogroups most of which have distinct geographic patterns. The haplogroups H5 and H6, both with the derived ADH1B*48His allele, appear restricted to the Middle East and East Asia, respectively. The positively selected H7 is derived from H6 by a new regulatory region variant defining SNP rs3811801 restricted to East Asia. Age estimates of the haplogroups based on the STRPs also agree with the time of the migration events estimated by other studies. H7 is estimated to have expanded recently, around 2,800 years ago, and ancient DNA samples from North China confirm its presence about that time. The dating of the H7 expansion may help understand the selective force on the ADH1B gene.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.