ArticleProceedings of the National Academy of Sciences of the United States of America1990
Persistent induction of cyclooxygenase in p60v-src-transformed 3T3 fibroblasts.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 84 citations in OpenAlex.
- The Differential Early Responses of Human Leukocytes to Influenza Virus and Respiratory Syncytial Virus.Pathogens (Basel, Switzerland) · 2025Article
- Rofecoxib, but not celecoxib, increases the risk of thromboembolic cardiovascular events in young adults-a nationwide registry-based study.European journal of clinical pharmacology · 2010Article
- Kinin b2 receptor mediates induction of cyclooxygenase-2 and is overexpressed in head and neck squamous cell carcinomas.Molecular cancer research : MCR · 2008Article
- COX-2 is essential for EGF induction of cell proliferation in gastric RGM1 cells.Digestive diseases and sciences · 2003Article
- Malignant transformation and antineoplastic actions of nonsteroidal antiinflammatory drugs (NSAIDs) on cyclooxygenase-null embryo fibroblasts.The Journal of experimental medicine · 1999Article
- Upregulation of vascular endothelial growth factor by cobalt chloride-simulated hypoxia is mediated by persistent induction of cyclooxygenase-2 in a metastatic human prostate cancer cell line.Clinical & experimental metastasis · 1999Article
- Leukoregulin induction of protein expression in human orbital fibroblasts: evidence for anatomical site-restricted cytokine-target cell interactions.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Topical glucocorticoids and the skin--mechanisms of action: an update.Mediators of inflammation · 1998Review
- Rapid and transient induction of cyclo-oxygenase 2 by epidermal growth factor in human amnion-derived WISH cells.The Biochemical journal · 1997Article
- Human immunodeficiency virus type 1 envelope protein does not stimulate either prostaglandin formation or the expression of prostaglandin H synthase in THP-1 human monocytes/macrophages.Journal of virology · 1995Article
- Regulation of prostaglandin synthase-1 and prostaglandin synthase-2.Cancer metastasis reviews · 1994Review
- v-src induction of the TIS10/PGS2 prostaglandin synthase gene is mediated by an ATF/CRE transcription response element.Molecular and cellular biology · 1994Article
- Lipopolysaccharide induces prostaglandin H synthase-2 protein and mRNA in human alveolar macrophages and blood monocytes.The Journal of clinical investigation · 1994Article
- Attenuated prostaglandin formation in peroxisomal-deficient human skin fibroblasts.The Journal of clinical investigation · 1993Article
- Fatty acid modulation of tumor cell-platelet-vessel wall interaction.Cancer metastasis reviews · 1992Review
- cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A BALB/c 3T3 cell line infected with the temperature-sensitive Rous sarcoma virus strain LA90 has been used to investigate early, p60v-src-dependent changes in gene expression (protein synthesis). Giant two-dimensional electrophoresis, which can resolve greater than 3000 polypeptides from [35S]methionine-labeled cell lysates, was used to detect the induction of a p72-74 (72-74 kDa) doublet (pI 7.5) after activation of p60v-src at 35 degrees C. Antiserum against cyclooxygenase (prostaglandin synthase or prostaglandin endoperoxide synthase) specifically immunoprecipitated the p72-74 doublet. The p72-74 doublet was also induced by platelet-derived growth factor and by phorbol 12-myristate 13-acetate and was elevated in an NIH 3T3 cell line transformed by wild-type src. Activation of p60v-src caused a persistent increase in p72-74, whereas the effect of the growth factor was transient. These dissimilar kinetics of induction were paralleled by changes in cyclooxygenase activity. Down-regulation of protein kinase C inhibited subsequent induction of cyclooxygenase by phorbol myristate acetate but did not block induction by p60v-src. The glucocorticoid agonist dexamethasone inhibited induction of cyclooxygenase by p60v-src. Although induction of this enzyme may not be directly involved in transformation, the data support the view that oncogenic transformation may result, not from expression of transformation-specific genes, but from persistent changes in the expression of genes normally induced only transiently during passage from the G0 stage of the cell cycle.
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