ArticleMagnetic resonance in medicine2011
MRI of blood flow of the human retina.
Article in Magnetic resonance in medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
33 citing papers in PubMed, 46 citations in OpenAlex.
- A moderate dosage of coffee causes acute retinal capillary perfusion decrease in healthy young individuals.BMC ophthalmology · 2022Trial
- Associations Between Retinal Microvasculature, Orbital Blood Flow, and Cerebral Blood Flow in Healthy Adults.Investigative ophthalmology & visual science · 2025Article
- Improved MRI methods to quantify retinal and choroidal blood flow applied to a model of glaucoma.Frontiers in ophthalmology · 2024Article
- Relationship between optical coherence tomography angiography and visual evoked potential in patients with multiple sclerosis.Indian journal of ophthalmology · 2022Article
- The effect of dobutamine on ocular blood flow of healthy adults: A 3D pseudocontinuous aterial spin labelling study.Frontiers in physiology · 2022Article
- Non-invasive Diagnosis and Prognosis Values of 3D Pseudocontinuous Arterial Spin Labeling and Optical Coherence Tomography Angiography in Proliferative Diabetic Retinopathy.Frontiers in medicine · 2021Article
- Measurement of retina/choroid complex perfusion with magnetic resonance imaging in eyes with acute primary angle-closure.Arquivos brasileiros de oftalmologia · 2021Article
- Diabetic mice have retinal and choroidal blood flow deficits and electroretinogram deficits with impaired responses to hypercapnia.PloS one · 2021Article
- Signal Strength as an Important Factor in the Analysis of Peripapillary Microvascular Density Using Optical Coherence Tomography Angiography.Scientific reports · 2019Article
- Imaging Retinal Activity in the Living Eye.Annual review of vision science · 2019Review
- Evaluating anesthetic protocols for functional blood flow imaging in the rat eye.Journal of biomedical optics · 2017Article
- Application of Arterial Spin Labelling in the Assessment of Ocular Tissues.BioMed research international · 2016Review
- Childhood extracranial neoplasms: the role of imaging in drug development and clinical trials.Pediatric radiology · 2015Review
- Choroidal blood flow decreases with age: an MRI study.Current eye research · 2014Article
- Optical coherence tomography angiography of optic nerve head and parafovea in multiple sclerosis.The British journal of ophthalmology · 2014Article
- Comparison of retinal and cerebral blood flow between continuous arterial spin labeling MRI and fluorescent microsphere techniques.Journal of magnetic resonance imaging : JMRI · 2014Article
- Magnetic resonance imaging of the retina: from mice to men.Magnetic resonance in medicine · 2014Review
- Laser speckle contrast imaging of blood flow in rat retinas using an endoscope.Journal of biomedical optics · 2013Article
- Balanced steady state free precession for arterial spin labeling MRI: Initial experience for blood flow mapping in human brain, retina, and kidney.Magnetic resonance imaging · 2013Article
- Decreased retinal-choroidal blood flow in retinitis pigmentosa as measured by MRI.Documenta ophthalmologica. Advances in ophthalmology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
This study reports a high-resolution MRI approach to image basal blood flow and hypercapnia-induced blood-flow changes in the unanesthetized human retina on a 3-T MRI scanner. Pseudocontinuous arterial spin labeling technique with static tissue suppression was implemented to minimize movement artifacts and improve blood-flow sensitivity. Turbo spin-echo acquisition was used to achieve high spatial resolution free of susceptibility artifacts. The size, shape, and position of a custom-made receive radiofrequency coil were optimized for sensitivity in the posterior retina. Synchronized eye blink and respiration to the end of each data readout minimized eye movement and physiological fluctuation. Robust high-contrast blood-flow MRI of the unanesthetized human retina was obtained at 500 × 800 μm(2) in-plane resolution. Blood flow in the posterior retina was 93 ± 31 mL/(100 mL min) (mean ± standard deviation, N = 5). Hypercapnic inhalation (5% CO(2)) increased blood flow by 12 ± 4% relative to air (P < 0.01, N = 5). This study demonstrates the feasibility of blood-flow MRI of the retina of unanesthetized human. Because blood flow is tightly coupled to metabolic function under normal conditions and it is often perturbed in diseases, this approach could provide unique insights into retinal physiology and serve as an objective imaging biomarker for disease staging and testing of novel therapeutic strategies. This approach could open up new avenue of retinal research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.