ArticleBioEssays : news and reviews in molecular, cellular and developmental biology2011
Why is it crucial to reintegrate pathology into cancer research?
Article in BioEssays : news and reviews in molecular, cellular and developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Impact of an evolving classification system on diffuse glioma repositories: experience from the Sydney brain tumour bank.Journal of neuro-oncology · 2026Article
- High-dimensional imaging using combinatorial channel multiplexing and deep learning.Nature biotechnology · 2026Article
- Foundation models in computational pathology: methods, applications and clinical implications.BMJ oncology · 2026Review
- A deep learning model for molecular label transfer that enables cancer cell identification from histopathology images.NPJ precision oncology · 2022Article
- Article
- The leading role of pathology in assessing the somatic molecular alterations of cancer: Position Paper of the European Society of Pathology.Virchows Archiv : an international journal of pathology · 2020Review
- [Histopathological research laboratories in translational research : Conception and integration into the infrastructure of pathological institutes].Der Pathologe · 2019Article
- Of mice and women: a comparative tissue biology perspective of breast stem cells and differentiation.Journal of mammary gland biology and neoplasia · 2015Review
- The use of sensitive chemical antibodies for diagnosis: detection of low levels of EpCAM in breast cancer.PloS one · 2013Article
- Tumor budding as a potential histopathological biomarker in colorectal cancer: hype or hope?World journal of gastroenterology · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The integration of pathology with molecular biology is vital if we are to enhance the translational value of cancer research. Pathology represents a bridge between medicine and basic biology, it remains the gold standard for cancer diagnosis, and it plays an important role in discovery studies. In the past, pathology and cancer research were closely associated; however, the molecular biology revolution has shifted the focus of investigators toward the molecular alterations of tumors. The reductionist approach taken in molecular studies is producing great insight into the inner workings of neoplasia, but it can also minimize the importance of histopathology and of understanding the disease as a whole. In turn, pathologists can underestimate the role of molecular studies in developing new ancillary techniques for clinical diagnosis. A multidisciplinary approach that integrates pathology and molecular biology within a translational research system is needed. This process will require overcoming cultural barriers and can be achieved through education, a more effective incorporation of pathology into biological research, and conversely an integration of biological research into the pathology laboratory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.