ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2011
Stronger bone correlates with African admixture in African-American women.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A Meta-Analysis of the Transferability of Bone Mineral Density Genetic Loci Associations From European to African Ancestry Populations.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021Pooled it
- Association between a literature-based genetic risk score and bone mineral density of African American women in Women Health Initiative Study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Pooled it
- Challenges of fracture risk assessment in Asian and Black women.The American journal of managed care · 2024Article
- Genetic ancestry and skeletal toxicities among childhood acute lymphoblastic leukemia patients in the DFCI 05-001 cohort.Blood advances · 2021Article
- Genetic admixture and body composition in Puerto Rican adults from the Boston Puerto Rican Osteoporosis Study.Journal of bone and mineral metabolism · 2017Article
- Biochemical and clinical deficiency is uncommon in African immigrants despite a high prevalence of low vitamin D: the Africans in America study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Article
- Vitamin D Associations With Renal, Bone, and Cardiovascular Phenotypes: African American-Diabetes Heart Study.The Journal of clinical endocrinology and metabolism · 2015Article
- Vitamin D metabolites and bone mineral density: The multi-ethnic study of atherosclerosis.Bone · 2015Article
- Women Build Long Bones With Less Cortical Mass Relative to Body Size and Bone Size Compared With Men.Clinical orthopaedics and related research · 2015Article
- Population ancestry and genetic risk for diabetes and kidney, cardiovascular, and bone disease: modifiable environmental factors may produce the cures.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2013Review
- Fibroblast growth factor 23, vitamin D, and health disparities among African Americans with chronic kidney disease.Seminars in nephrology · 2013Review
- Association of DXA-derived bone mineral density and fat mass with African ancestry.The Journal of clinical endocrinology and metabolism · 2013Article
- Hip geometry in diabetic women: implications for fracture risk.Metabolism: clinical and experimental · 2012Article
- Health disparities in endocrine disorders: biological, clinical, and nonclinical factors--an Endocrine Society scientific statement.The Journal of clinical endocrinology and metabolism · 2012Article
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9 authors.
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Abstract
Osteoporosis affects all populations, but the risk for low bone density and fracture varies greatly by self-reported race and ethnicity. In this article, the relationship between measured percent African admixture and hip structural geometry, estimated from the hip structural analysis (HSA) program, was examined in a subcohort of the Women's Health Initiative (WHI). The study sample included 793 African-American women and 8559 non-Hispanic white women. All the participants were postmenopausal, between the ages of 50 and 79 years, at the time of recruitment and were followed for up to 9 years. Bone density and hip geometry were assessed using dual-energy X-ray absorptiometry. African admixture was measured for African Americans using genetic ancestry informative markers. Multiple regression and mixed-effects models were used for cross-sectional and longitudinal analyses, respectively. Covariates assessed from questionnaires and physical measurements were included in the analysis to control for possible confounding effects. The study results show significant correlations between percent of African admixture and HSA assessments. In comparison with non-Hispanic white women, significantly greater bone strength, as indicated by higher hip bone mineral density and stronger hip geometry, in women with higher African admixture was observed. However, women with higher percent African admixture had larger reductions in bone strength than non-Hispanic white women during the follow-up.
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