ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2011
Volumetric bone mineral density and bone structure in childhood chronic kidney disease.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04071548 (The Effect of Exercise on Muscle Dysfunction in Cystinosis), which is not on this map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Exercise on Muscle Dysfunction in Cystinosis
Who cites it
33 citing papers in PubMed, 54 citations in OpenAlex.
- Bioelectrical Impedance in Pediatric Dialysis: Clinical Applications, Limitations, and Opportunities.Hemodialysis international. International Symposium on Home Hemodialysis · 2026Review
- Circulating Fibroblast Growth Factor-21 Levels in Rheumatoid Arthritis: Associations With Disease Characteristics, Body Composition, and Physical Functioning.The Journal of rheumatology · 2021Article
- Association of Low Muscle Density With Deteriorations in Muscle Strength and Physical Functioning in Rheumatoid Arthritis.Arthritis care & research · 2021Article
- Cinacalcet studies in pediatric subjects with secondary hyperparathyroidism receiving dialysis.Pediatric nephrology (Berlin, Germany) · 2020Review
- Assessing bone mineralisation in children with chronic kidney disease: what clinical and research tools are available?Pediatric nephrology (Berlin, Germany) · 2020Review
- Treatment of hyperphosphatemia: the dangers of high PTH levels.Pediatric nephrology (Berlin, Germany) · 2020Review
- Skeletal Morbidity in Children and Adolescents during and following Cancer Therapy.Hormone research in paediatrics · 2019Review
- Intramuscular Fat Accumulation and Associations With Body Composition, Strength, and Physical Functioning in Patients With Rheumatoid Arthritis.Arthritis care & research · 2018Observational
- The interplay between bone and vessels in pediatric CKD: lessons from a single-center study.Pediatric nephrology (Berlin, Germany) · 2018Article
- Muscle wasting in chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2018Review
- Cortical and trabecular bone are equally affected in rats with renal failure and secondary hyperparathyroidism.BMC nephrology · 2018Article
- Muscle Deficits in Rheumatoid Arthritis Contribute to Inferior Cortical Bone Structure and Trabecular Bone Mineral Density.The Journal of rheumatology · 2017Article
- Peripheral quantitative computed tomography (pQCT) for the assessment of bone strength in most of bone affecting conditions in developmental age: a review.Italian journal of pediatrics · 2016Review
- Micro-CT in the Assessment of Pediatric Renal Osteodystrophy by Bone Histomorphometry.Clinical journal of the American Society of Nephrology : CJASN · 2016Article
- Reduced skeletal muscle function is associated with decreased fiber cross-sectional area in the Cy/+ rat model of progressive kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2016Article
- Fracture Burden and Risk Factors in Childhood CKD: Results from the CKiD Cohort Study.Journal of the American Society of Nephrology : JASN · 2016Article
- Association of bone mineral density with biochemical markers of bone turnover in hemodialysis children.Journal of renal injury prevention · 2016Article
- Article
- Longitudinal assessment of bone quality in pediatric patients with chronic kidney disease in relation to treatment modality.Journal of bone and mineral metabolism · 2015Article
- Cortical and trabecular bone in pediatric end-stage kidney disease.Pediatric nephrology (Berlin, Germany) · 2015Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
Chronic kidney disease (CKD) is associated with increased fracture risk and skeletal deformities. The impact of CKD on volumetric bone mineral density (vBMD) and cortical dimensions during growth is unknown. Tibia quantitative computed tomographic scans were obtained in 156 children with CKD [69 stages 2 to 3, 51 stages 4 to 5, and 36 stage 5D (dialysis)] and 831 healthy participants aged 5 to 21 years. Sex-, race-, and age- or tibia length-specific Z-scores were generated for trabecular BMD (TrabBMD), cortical BMD (CortBMD), cortical area (CortArea) and endosteal circumference (EndoC). Greater CKD severity was associated with a higher TrabBMD Z-score in younger participants (p < .001) compared with healthy children; this association was attenuated in older participants (interaction p < .001). Mean CortArea Z-score was lower (p < .01) in CKD 4-5 [-0.49, 95% confidence interval (CI) -0.80, -0.18)] and CKD 5D (-0.49, 95% CI -0.83, -0.15) compared with healthy children. Among CKD participants, parathyroid hormone (PTH) levels were positively associated with TrabBMD Z-score (p < .01), and this association was significantly attenuated in older participants (interaction p < .05). Higher levels of PTH and biomarkers of bone formation (bone-specific alkaline phosphatase) and resorption (serum C-terminal telopeptide of type 1 collagen) were associated with lower CortBMD and CortArea Z-scores and greater EndoC Z-score (r = 0.18-0.36, all p ≤ .02). CortBMD Z-score was significantly lower in CKD participants with PTH levels above versus below the upper limit of the Kidney Disease Outcome Quality Initiative (KDOQI) CKD stage-specific target range: -0.46 ± 1.29 versus 0.12 ± 1.14 (p < .01). In summary, childhood CKD and secondary hyperparathyroidism were associated with significant reductions in cortical area and CortBMD and greater TrabBMD in younger children. Future studies are needed to establish the fracture implications of these alterations and to determine if cortical and trabecular abnormalities are reversible.
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