ReviewJournal of neurology2011
New insights into the pathophysiology of pes cavus in Charcot-Marie-Tooth disease type 1A duplication.
Review in Journal of neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Dynamic gait phase alterations and spatiotemporal stance characteristics in bilateral pes cavus: A case-control study.PloS one · 2026Observational
- The Heidelberg Functional Foot Model-Application to Cavovarus and Equinovarus Feet.Journal of foot and ankle research · 2025Article
- The fibularis longus muscle revisited: comparative anatomy, developmental perspectives, and clinical relevance.Frontiers in cell and developmental biology · 2025Review
- The variability of isokinetic ankle strength is different in healthy older men and women.Clinics (Sao Paulo, Brazil) · 2022Article
- Management of gait impairments in people with Charcot-Marie-Tooth disease: A treatment algorithm.Journal of rehabilitation medicine · 2021Article
- LRSAM1 and the RING domain: Charcot-Marie-Tooth disease and beyond.Orphanet journal of rare diseases · 2021Review
- The adult cavus foot.EFORT open reviews · 2017Article
- Evolution of Charcot-Marie-Tooth disease type 1A duplication: a 2-year clinico-electrophysiological and lower-limb muscle MRI longitudinal study.Journal of neurology · 2014Article
- Hereditary neuropathy with liability to pressure palsy: fulminant radicular dysfunction during anterolateral lumbar interbody fusion.Journal of neurology · 2013Article
- Clinical neurogenetics: recent advances.Journal of neurology · 2012Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Forefoot pes cavus is a cardinal sign of Charcot-Marie-Tooth disease (CMT). This review is focused on the pathophysiology of pes cavus in CMT1A duplication, which is the most common subtype of the disease. Assessment of foot deformities in CMT1A, their prevalence and proposed mechanisms, and recent contributions of magnetic resonance imaging studies of lower-leg and foot musculature are revised. Special attention is given to papers on foot deformities at initial stages of the disease. We conclude that pes cavus is an early and age-dependent manifestation of CMT1A duplication. Selective denervation of intrinsic foot musculature, particularly of the lumbricals, and not imbalance of lower-leg muscles, seems to be the initial mechanism causing reduced ankle flexibility and forefoot cavus deformity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.