ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2011
Overexpression of matrix metalloproteinase-21 is associated with poor overall survival of patients with colorectal cancer.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Photodynamic Therapy Targeting Matrix Metalloproteases in Cancer: Standpoint for an Innovative Anticancer Strategy.Current issues in molecular biology · 2026Review
- Migration and invasion of cancer stem cells are prevented by low-intensity pulsed ultrasound therapy.Cancer cell international · 2025Article
- Matrix metalloproteinase-21 promotes metastasis via increasing the recruitment and M2 polarization of macrophages in HCC.Cancer science · 2023Article
- De novo disruptive heterozygous MMP21 variants are potential predisposing genetic risk factors in Chinese Han heterotaxy children.Human genomics · 2022Article
- Insights into the Role of Matrix Metalloproteinases in Precancerous Conditions and in Colorectal Cancer.Cancers · 2021Review
- ADAM17 promotes the invasion of hepatocellular carcinoma via upregulation MMP21.Cancer cell international · 2020Article
- Overexpression of G protein-coupled receptor 31 as a poor prognosticator in human colorectal cancer.World journal of gastroenterology · 2018Article
- Overexpression of MMP21 and MMP28 is associated with gastric cancer progression and poor prognosis.Oncology letters · 2018Article
- High expression of cytoplasmic polyadenylation element-binding protein 4 correlates with poor prognosis of patients with colorectal cancer.Virchows Archiv : an international journal of pathology · 2017Article
- Overexpression of Hexokinase 1 as a poor prognosticator in human colorectal cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Regulation and involvement of matrix metalloproteinases in vascular diseases.Frontiers in bioscience (Landmark edition) · 2016Review
- A human laterality disorder caused by a homozygous deleterious mutation in MMP21.Journal of medical genetics · 2015Article
- Up-regulation of Tim-3 is associated with poor prognosis of patients with colon cancer.International journal of clinical and experimental pathology · 2015Article
- Decreased miR-30b-5p expression by DNMT1 methylation regulation involved in gastric cancer metastasis.Molecular biology reports · 2014Article
- Increased MMP-21 expression in esophageal squamous cell carcinoma is associated with progression and prognosis.Medical oncology (Northwood, London, England) · 2014Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMatrix metalloproteinase-21 (MMP-21) is a member of the MMP family, which is overexpressed in some solid tumors and is thought to enhance the tumor invasion and metastasis ability. The aim of the present study is to examine the MMP-21 expression in human colorectal cancer and normal colorectal tissue using tissue microarray technique and to determine its association with clinicopathological characteristics and prognostic value. MATERIALS AND
methodsFour array blocks including 256 cases of colorectal cancer and adjacent normal tissues were investigated by immunohistochemistry assay. Staining evaluation results were analyzed statistically in relation to various clinicopathological characters and overall survival.
resultsHigh level of MMP-21 expression was detected in colorectal cancer, significantly more than in normal colorectal epithelial cells. In colorectal cancer, MMP-21 was significantly positively correlated with depth of invasion, lymph node metastasis, and distant metastasis. The overall survival rate was significantly lower for patients with MMP-21 positive than those with MMP-21 negative tumors. However, no correlations between MMP-21 expression and patients' age, sex tumor location, or differentiation status were detected.
conclusionOur findings emphasize the important role of MMP-21 in the invasion and metastasis process in human colorectal cancer. It might also serve as a novel prognostic marker that is independent of, and additive to, the TNM staging system.
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