ArticleMolecular bioSystems2011
Transcriptional regulation by miRNA mimics that target sequences downstream of gene termini.
Article in Molecular bioSystems, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
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- Small Interfering RNAs Targeting a Chromatin-Associated RNA Induce Its Transcriptional Silencing in Human Cells.Molecular and cellular biology · 2022Article
- Evidence for miR-548c-5p regulation of FOXC2 transcription through a distal genomic target site in human podocytes.Cellular and molecular life sciences : CMLS · 2020Article
- Terminus-Associated Non-coding RNAs: Trash or Treasure?Frontiers in genetics · 2020Review
- Regulatory network of miRNA on its target: coordination between transcriptional and post-transcriptional regulation of gene expression.Cellular and molecular life sciences : CMLS · 2019Review
- Classification of Transcription Boundary-Associated RNAs (TBARs) in Animals and Plants.Frontiers in genetics · 2018Review
- Anticancer Natural Compounds as Epigenetic Modulators of Gene Expression.Current genomics · 2017Review
- MicroRNA in Control of Gene Expression: An Overview of Nuclear Functions.International journal of molecular sciences · 2016Review
- Post-transcriptional gene silencing, transcriptional gene silencing and human immunodeficiency virus.World journal of virology · 2015Review
- Progesterone: a universal stimulus for neuronal cells?Neural regeneration research · 2015Article
- The MicroRNA Biology of the Mammalian Nucleus.Molecular therapy. Nucleic acids · 2014Article
- Article
- Phospho-ΔNp63α/microRNA network modulates epigenetic regulatory enzymes in squamous cell carcinomas.Cell cycle (Georgetown, Tex.) · 2014Article
- Tumor Protein p63/microRNA Network in Epithelial Cancer Cells.Current genomics · 2013Article
- Transcriptional targeting by microRNA-polycomb complexes: a novel route in cell fate determination.Cell cycle (Georgetown, Tex.) · 2012Article
- miRNA goes nuclear.RNA biology · 2012Review
- Argonaute and the nuclear RNAs: new pathways for RNA-mediated control of gene expression.Nucleic acid therapeutics · 2012Review
- Upregulation of Cyclin B1 by miRNA and its implications in cancer.Nucleic acids research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Transcriptome studies have revealed that protein-coding loci within the human genome are overlapped at their 3'-termini by noncoding RNA (ncRNA) transcripts. Small duplex RNAs designed to be fully complementary to these 3' ncRNAs can modulate transcription of the upstream gene. Robust regulation by designed RNAs suggests that endogenous small RNAs might also recognize 3' ncRNAs and regulate gene expression. A genome-wide evaluation revealed that sequences immediately downstream of protein-coding genes are enriched with miRNA target sites. We experimentally tested miRNA mimics complementary to the well-characterized 3'-terminus of the human progesterone receptor (PR) gene and observed inhibition of PR transcription. These results suggest that recognition of ncRNA transcripts that overlap gene termini may be a natural function of endogenous small RNAs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.