ArticlePediatric reports2010
Hyperuricemia in obese children and adolescents: the relationship with metabolic syndrome.
Article in Pediatric reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 58 citations in OpenAlex.
- The global landscape of pediatric hyperuricemia research: a bibliometric roadmap to mechanisms, management, and future therapeutics (1997-2024).Translational pediatrics · 2026Article
- Uric Acid Metabolism and Its Relationship with Glucose and Lipid Metabolism in Overweight and Obese Children and Adolescents: A Cross-Sectional Study in South China.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Prevalence of and trends in hyperuricemia by race and ethnicity among US adolescents, 1999-2018.Arthritis research & therapy · 2024Article
- Lactoferrin in Pediatric Chronic Kidney Disease and Its Relationship with Cardiovascular Risk.Children (Basel, Switzerland) · 2024Article
- Article
- A Gender-, Age-, and Weight Status-Specific Analysis of the High Prevalence of Hyperuricemia Among Chinese Children and Adolescents with Obesity.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Association of serum uric acid Levels with metabolic syndromes in Korean adolescents.Frontiers in endocrinology · 2023Article
- Salivary uric acid across child development and associations with weight, height, and body mass index.Frontiers in pediatrics · 2023Article
- Prevalence and factors related to hypouricemia and hyperuricemia in schoolchildren: results of a large-scale cross-sectional population-based study conducted in Japan.Scientific reports · 2022Article
- In Vitro Mimicking of Obesity-Induced Biochemical Environment to Study Obesity Impacts on Cells and Tissues.Diseases (Basel, Switzerland) · 2022Article
- Impact of Lifestyle Modifications on Alterations in Lipid and Glycemic Profiles and Uric Acid Values in a Pediatric Population.Nutrients · 2022Article
- Skeletal Muscle Mass Has Stronger Association With the Risk of Hyperuricemia Than Body Fat Mass in Obese Children and Adolescents.Frontiers in nutrition · 2022Article
- Investigating the relationship between serum uric acid to high-density lipoprotein ratio and metabolic syndrome.Endocrinology, diabetes & metabolism · 2022Article
- Urate-lowering therapy for gout and asymptomatic hyperuricemia in the pediatric population: a cross-sectional study of a Japanese health insurance database.BMC pediatrics · 2021Article
- Fat Mass Index Associated with Blood Pressure Abnormalities in Children with Chronic Kidney Disease.Children (Basel, Switzerland) · 2021Article
- Prevalence of gout and asymptomatic hyperuricemia in the pediatric population: a cross-sectional study of a Japanese health insurance database.BMC pediatrics · 2020Observational
- Combined effects of dietary zinc at 3 years of age and obesity at 7 years of age on the serum uric acid levels of Korean children.Nutrition research and practice · 2020Article
- Metabolic biomarkers and long-term blood pressure variability in military young male adults.World journal of clinical cases · 2020Article
- Marked Influence of Adiposity on Laboratory Biomarkers in a Healthy Cohort of Children and Adolescents.The Journal of clinical endocrinology and metabolism · 2020Article
- Asymptomatic Hyperuricemia Associates with Cardiometabolic Risk Indicators in Overweight/Obese but Not in Lean Adolescents.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence of hyperuricemia in obese children and adolescents and its association with metabolic syndrome are largely unknown. The objective of our study was to characterize hyperuricemia in relation to metabolic syndrome in Japanese children and adolescents with obesity. Between 2005 and 2008, we performed a cross-sectional study of 1,027 obese children and adolescents aged 6-14 years. Based on the reference value of serum uric acid we had established previously, hyperuricemia was defined as one standard deviation over the mean value at each age. The diagnosis of metabolic syndrome was made based on the Japanese criteria for children. A total of 213 children and adolescents (20.7%) was found to have hyperuricemia. The prevalence of hyperuricemia was significantly higher in the male gender and older age group. Sixty-five out of 213 subjects with hyperuricemia (30.5%) had metabolic syndrome, whereas 111 out of 814 subjects without hyperuricemia (13.6%) had metabolic syndrome. The most common abnormal component of metabolic syndrome was triglyceride, followed by diastolic blood pressure, systolic blood pressure, fasting blood glucose, and HDL-cholesterol. Such a tendency was almost identical between the two groups. We concluded that considering the association between hyperuricemia and metabolic syndrome in obese Japanese children and adolescents, the role of hyperuricemia in metabolic syndrome should receive more attention, beginning in early childhood.
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