ArticleBritish journal of cancer2011
A multimarker QPCR-based platform for the detection of circulating tumour cells in patients with early-stage breast cancer.
Article in British journal of cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Circulating tumor cells in breast cancer and its association with tumor clinicopathological characteristics: a meta-analysis.Medical oncology (Northwood, London, England) · 2014Pooled it
- miR-10a as a therapeutic target and predictive biomarker for MDM2 inhibition in acute myeloid leukemia.Leukemia · 2021Article
- Characterization of circulating tumor cells in early breast cancer patients receiving neoadjuvant chemotherapy.Therapeutic advances in medical oncology · 2021Article
- DNA Microsystems for Biodiagnosis.Micromachines · 2020Review
- Laparoscopic surgery for early cervical squamous cell carcinoma and its effect on the micrometastasis of cancer cells.Medicine · 2018Observational
- Cell-free circulating DNA integrity is an independent predictor of impending breast cancer recurrence.Oncotarget · 2017Article
- Long non-coding RNA HOXA-AS2 promotes proliferation and invasion of breast cancer by acting as a miR-520c-3p sponge.Oncotarget · 2017Article
- Nerve growth factor: role in growth, differentiation and controlling cancer cell development.Journal of experimental & clinical cancer research : CR · 2016Review
- Real-Time qPCR-Based Detection of Circulating Tumor Cells from Blood Samples of Adjuvant Breast Cancer Patients: A Preliminary Study.Breast care (Basel, Switzerland) · 2016Article
- Single cell analysis of cancer cells using an improved RT-MLPA method has potential for cancer diagnosis and monitoring.Scientific reports · 2015Article
- The long noncoding RNA SPRY4-IT1 increases the proliferation of human breast cancer cells by upregulating ZNF703 expression.Molecular cancer · 2015Article
- Clinical implications of circulating tumor cells of breast cancer patients: role of epithelial-mesenchymal plasticity.Frontiers in oncology · 2015Review
- Mesenchymal phenotype of CTC-enriched blood fraction and lymph node metastasis formation potential.PloS one · 2014Article
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- Molecular detection of peripheral blood breast cancer mRNA transcripts as a surrogate biomarker for circulating tumor cells.PloS one · 2013Article
- A novel method for the in vivo isolation of circulating tumor cells from peripheral blood of cancer patients using a functionalized and structured medical wire.International journal of oncology · 2012Article
- The dynamic change of circulating tumour cells in patients with operable breast cancer before and after chemotherapy based on a multimarker QPCR platform.British journal of cancer · 2012Article
- Progress in circulating tumor cell capture and analysis: implications for cancer management.Expert review of molecular diagnostics · 2012Review
- A prognostic gene expression profile that predicts circulating tumor cell presence in breast cancer patients.PloS one · 2012Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe detection of circulating tumour cells (CTCs) has been linked with poor prognosis in advanced breast cancer. Relatively few studies have been undertaken to study the clinical relevance of CTCs in early-stage breast cancer.
methodsIn a prospective study, we evaluated CTCs in the peripheral blood of 82 early-stage breast cancer patients. Control groups consisted of 16 advanced breast cancer patients and 45 healthy volunteers. The CTC detection was performed using ErbB2/EpCAM immunomagnetic tumour cell enrichment followed by multimarker quantitative PCR (QPCR). The CTC status and common clinicopathological factors were correlated to relapse-free, breast cancer-related and overall survival.
resultsCirculating tumour cells were detected in 16 of 82 (20%) patients with early-stage breast cancer and in 13 out of 16 (81%) with advanced breast cancer. The specificity was 100%. The median follow-up time was 51 months (range: 17-60). The CTC positivity in early-stage breast cancer patients resulted in significantly poorer relapse-free survival (log rank test: P=0.003) and was an independent predictor of relapse-free survival (multivariate hazard ratio=5.13, P=0.006, 95% CI: 1.62-16.31).
conclusionThe detection of CTCs in peripheral blood of early-stage breast cancer patients provided prognostic information for relapse-free survival.
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