Evidence map›Paper›PMID 21587229›Full record

ArticleNature communications2011

Active microrheology and simultaneous visualization of sheared phospholipid monolayers.

S Q Choi, S Steltenkamp, J A Zasadzinski, T M Squires

Abstract readEvaluation Study
In one paragraph

Article in Nature communications, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Experimental Observations of Graphene at Phospholipid Monolayers.Langmuir : the ACS journal of surfaces and colloids · 2026
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  15. Evolution and mechanics of mixed phospholipid fibrinogen monolayers.Journal of the Royal Society, Interface · 2018
    Article
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  17. Nonequilibrium fluctuations of lipid membranes by the rotating motor protein FProceedings of the National Academy of Sciences of the United States of America · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

S Q ChoiDepartment of Chemical Engineering, University of California-Santa Barbara, Santa Barbara, California 93106, USA.
S Steltenkamp
J A Zasadzinski
T M Squires

Funding

LIPID AND PROTEIN EFFECTS ON MONOLAYER STABILITYR01HL051177 · NHLBI · UNIVERSITY OF MINNESOTA · PI Joseph Anthony Zasadzinski · 1994 to 2026
$9.5M
Myelin Composition Influence on Bilayer Interactions in Multiple SclerosisR01GM076709 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI ISRAELACHVILI, JACOB N · 2007 to 2010
$1.1M
NHLBI NIH HHS HL-51177NHLBI NIH HHS R01 HL051177NIGMS NIH HHS GM076709NIGMS NIH HHS R01 GM076709
6 · The paper itself

Abstract

Two-dimensional films of surface-active agents-from phospholipids and proteins to nanoparticles and colloids-stabilize fluid interfaces, which are essential to the science, technology and engineering of everyday life. The 2D nature of interfaces present unique challenges and opportunities: coupling between the 2D films and the bulk fluids complicates the measurement of surface dynamic properties, but allows the interfacial microstructure to be directly visualized during deformation. Here we present a novel technique that combines active microrheology with fluorescence microscopy to visualize fluid interfaces as they deform under applied stress, allowing structure and rheology to be correlated on the micron-scale in monolayer films. We show that even simple, single-component lipid monolayers can exhibit viscoelasticity, history dependence, a yield stress and hours-long time scales for elastic recoil and aging. Simultaneous visualization of the monolayer under stress shows that the rich dynamical response results from the cooperative dynamics and deformation of liquid-crystalline domains and their boundaries.

Indexed as

Microscopy, FluorescencePhospholipidsRheologySurface PropertiesViscosityPhospholipids

Identifiers

PMID21587229
PMCPMC3113294

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.