Evidence map›Paper›PMID 21587223›Full record

ReviewNature reviews. Urology2011

A decade in prostate cancer: from NMR to metabolomics.

Elita M DeFeo, Chin-Lee Wu, W Scott McDougal, Leo L Cheng

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Urology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Exploring metabolic signatures in urine using NMR for improved prognosis of gliomas.Metabolomics : Official journal of the Metabolomic Society · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Novel Metabolic Signatures of Prostate Cancer Revealed byDiagnostics (Basel, Switzerland) · 2021
    Article
  7. Review
  8. Article
  9. Article
  10. NMR-based metabolomics studies of human prostate cancer tissue.Metabolomics : Official journal of the Metabolomic Society · 2018
    Review
  11. Article
  12. Article
  13. Review
  14. Metabolomics connects aberrant bioenergetic, transmethylation, and gut microbiota in sarcoidosis.Metabolomics : Official journal of the Metabolomic Society · 2016
    Article
  15. Metabolomic profiling of hormone-dependent cancers: a bird's eye view.Trends in endocrinology and metabolism: TEM · 2015
    Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Sarcosine as a potential prostate cancer biomarker--a review.International journal of molecular sciences · 2013
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Elita M DeFeoDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.
Chin-Lee Wu
W Scott McDougal
Leo L Cheng

Funding

Characterizing Prostate Cancer By ex vivo MRS SignaturesR01CA115746 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CHENG, LEO L · 2006 to 2017
$6.4M
Detection of Lung Cancer Risks for Serum MetabolomicsR21CA141139 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CHENG, LEO L · 2010 to 2011
$432k
NCI NIH HHS CA115746NCI NIH HHS CA115746S2NCI NIH HHS CA141139
6 · The paper itself

Abstract

Over the past 30 years, continuous progress in the application of nuclear magnetic resonance (NMR) spectroscopy and magnetic resonance spectroscopic imaging (MRSI) to the detection, diagnosis and characterization of human prostate cancer has turned what began as scientific curiosity into a useful clinical option. In vivo MRSI technology has been integrated into the daily care of prostate cancer patients, and innovations in ex vivo methods have helped to establish NMR-based prostate cancer metabolomics. Metabolomic and multimodality imaging could be the future of the prostate cancer clinic--particularly given the rationale that more accurate interrogation of a disease as complex as human prostate cancer is most likely to be achieved through paradigms involving multiple, instead of single and isolated, parameters. The research and clinical results achieved through in vivo MRSI and ex vivo NMR investigations during the first 11 years of the 21st century illustrate areas where these technologies can be best translated into clinical practice.

Indexed as

Magnetic Resonance SpectroscopyAnimalsHumansMaleMetabolomicsProstatic Neoplasms

Identifiers

PMID21587223

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.