ArticleJournal of veterinary science2011
The stress of weaning influences serum levels of acute-phase proteins, iron-binding proteins, inflammatory cytokines, cortisol, and leukocyte subsets in Holstein calves.
Article in Journal of veterinary science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 124 citations in OpenAlex.
- Assessment of selected nutritional, bone metabolic and stress-related biomarkers across the weaning transition in naturally suckled Japanese Black calves.The Journal of veterinary medical science · 2026Article
- Effects of Timing of Injectable Trace Mineral Administration on Beef Calf Performance and Health Following Simulated Marketing.Animals : an open access journal from MDPI · 2026Article
- Identification of Risk Factors Associated with Treatment for BRD in Beef Calves Within the First 60 Days After Arrival at Fattening Operations in Northwestern Italy Beef Calves.Veterinary sciences · 2025Article
- The impact of stress in domestic animals: roles of heat shock proteins and acute-phase proteins.Veterinary research communications · 2025Review
- Weaning as Stressor for Calf Welfare.Animals : an open access journal from MDPI · 2025Article
- Butyrate Supplementation Improves Intestinal Health and Growth Performance in Livestock: A Review.Biomolecules · 2025Review
- Monitoring the effects of oxidative stress on the growth of Holstein bull calves using Diquat.Frontiers in veterinary science · 2025Article
- Impact of Parenteral Maternal Supplementation with Trace Minerals and Vitamins on Neonatal Calf Antioxidant System and Growth in a Dairy Herd.Animals : an open access journal from MDPI · 2024Article
- Average Daily Gain in Lambs Weaned at 60 Days of Age Is Correlated with Rumen and Rectum Microbiota.Microorganisms · 2023Article
- Article
- Impact of dietary supplementation of β-hydroxybutyric acid on performance, nutrient digestibility, organ development and serum stress indicators in early-weaned goat kids.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- Defining Fatty Acid Changes Linked to Rumen Development, Weaning and Growth in Holstein-Friesian Heifers.Metabolites · 2022Article
- Article
- Early Life Fecal Microbiota Transplantation in Neonatal Dairy Calves Promotes Growth Performance and Alleviates Inflammation and Oxidative Stress during Weaning.Animals : an open access journal from MDPI · 2021Article
- The Combined Effect of Weaning Stress and Immune Activation during Pig Gestation on Serum Cytokine and Analyte Concentrations.Animals : an open access journal from MDPI · 2021Article
- Transcriptional Profiles of Genes Related to Stress and Immune Response in Rainbow Trout (Frontiers in immunology · 2021Article
- The Role of Polyphenols in Regulation of Heat Shock Proteins and Gut Microbiota in Weaning Stress.Oxidative medicine and cellular longevity · 2021Review
- Effects of conditioning, source, and rest on indicators of stress in beef cattle transported by road.PloS one · 2021Article
- Increased serum levels of advanced glycation end products due to induced molting in hen layers trigger a proinflammatory response by peripheral blood leukocytes.Poultry science · 2020Article
- Technical note: fluorescein as an indicator of enteric mucosal barrier function in preruminant lambs.Journal of animal science · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of our study was to investigate changes in immunological parameters induced by weaning stress (including milk restriction) in calves. Fifteen Holstein calves were subjected to weaning at 6 weeks of age. Blood samples were collected at -14, -7, -2, 1, 3, and 5 days post-weaning (DPW; 0 DPW = 42 days). Weaning caused significant (p < 0.01) increases in the neutrophil (NE):lymphocyte (LY) ratio at 5 DPW with a significant (p < 0.05) reduction of LYs. The concentration of acute-phase proteins (haptoglobin and serum amyloid A) also increased significantly (p < 0.05) at 3 and 5 DPW compared to -2 DPW. Levels of the iron-binding protein lactoferrin decreased significantly (p < 0.05) after weaning. Serum tumor necrosis factor-α and cortisol levels were elevated (p < 0.05) at 3 DPW, while those of serum interferon-γ decreased (p < 0.05) at 1 and 3 DPW compared to levels observed before weaning. Weaning significantly (p < 0.05) decreased the percentage of CD25(+) T cells in the peripheral blood. In conclusion, weaning stress affected the NE:LY ratio along with the levels of acute phase proteins, lactoferrin, cortisol, and inflammatory cytokines in the peripheral blood of calves. Weaning stress may induce an acute phase response possibly through the elevation of cortisol production and modulation of inflammatory cytokines.
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