Evidence map›Paper›PMID 21586757›Full record

ArticleEmergency medicine journal : EMJ2012

The Acute Asthma Severity Assessment Protocol (AASAP) study: objectives and methods of a study to develop an acute asthma clinical prediction rule.

Donald H Arnold, Tebeb Gebretsadik, Thomas J Abramo, James R Sheller, Donald J Resha, Tina V Hartert

Open access · greenAbstract read
In one paragraph

Article in Emergency medicine journal : EMJ, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Article
  5. The asthma prediction rule to decrease hospitalizations for children with asthma.Current opinion in allergy and clinical immunology · 2016
    Review
  6. Pulse Oximeter Plethysmograph Estimate of Pulsus Paradoxus as a Measure of Acute Asthma Exacerbation Severity and Response to Treatment.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2016
    Observational
  7. Fractional exhaled nitric oxide change in pediatric patients after emergency department care of asthma exacerbations.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2015
    Article
  8. Article
  9. Spirometry and PRAM severity score changes during pediatric acute asthma exacerbation treatment in a pediatric emergency department.The Journal of asthma : official journal of the Association for the Care of Asthma · 2013
    Article
  10. Noninvasive testing of lung function and inflammation in pediatric patients with acute asthma exacerbations.The Journal of asthma : official journal of the Association for the Care of Asthma · 2012
    Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Donald H ArnoldDepartment of Pediatrics and Emergency Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. don.arnold@vanderbilt.edu
Tebeb Gebretsadik
Thomas J Abramo
James R Sheller
Donald J Resha
Tina V Hartert
Vanderbilt University · USMonroe Carell Jr. Children's Hospital · US

Funding

VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR) KL2KL2RR024977 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$3.0M
Midcareer Investigator Patient-oriented Research Award in Bronchiolitis & AsthmaK24AI077930 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARTERT, TINA V · 2008 to 2017
$1.6M
The Vanderbilt Institute for Clinical and Translational Research (VICTR) TL1TL1RR024978 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$1.3M
Development of a Pediatric Acute Asthma Prediction Rule for severity and outcomeK23HL080005 · NHLBI · VANDERBILT UNIVERSITY · PI ARNOLD, DONALD HAYES · 2008 to 2012
$738k
NCRR NIH HHS KL2 RR024977NCRR NIH HHS TL1 RR024978NCRR NIH HHS UL1 RR024975NHLBI NIH HHS K23 HL080005NHLBI NIH HHS K23 HL80005NIAID NIH HHS K24 AI077930NIAID NIH HHS K24 AI77930
6 · The paper itself

Abstract

Acute asthma exacerbations are one of the most common reasons for paediatric emergency department visits and hospitalisations, and a relapse frequently necessitates repeat urgent care. While care plans exist, there are no acute asthma prediction rules (APRs) to assess severity and predict outcome. The primary objective of the Acute Asthma Severity Assessment Protocol study is to develop a multivariable APR for acute asthma exacerbations in paediatric patients. A prospective, convenience sample of paediatric patients aged 5-17 years with acute asthma exacerbations who present to an urban, academic, tertiary paediatric emergency department was enrolled. The study protocol and data analysis plan conform to accepted biostatistical and clinical standards for clinical prediction rule development. Modelling of the APR will be performed once the entire sample size of 1500 has accrued. It is anticipated that the APR will improve resource utilisation in the emergency department, aid in standardisation of disease assessment and allow physician and non-physician providers to participate in earlier objective decision making. The objective of this report is to describe the study objectives and detailed methodology of the Acute Asthma Severity Assessment Protocol study.

Indexed as

Acute DiseaseAdolescentAsthmaChildChild, PreschoolClinical ProtocolsEmergency Service, HospitalFemaleHumansMaleModels, TheoreticalMultivariate AnalysisPredictive Value of TestsProspective StudiesRespiratory Function TestsSeverity of Illness Index

Identifiers

PMID21586757
PMCPMC3813951
OpenAlexW2158868437

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.