ArticleThe Journal of biological chemistry2011
Regulation of pyruvate dehydrogenase kinase 4 (PDK4) by CCAAT/enhancer-binding protein beta (C/EBPbeta).
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- VGLL4 enhances PDK4 transcription and promotes metabolic dysfunction-associated fatty liver disease.EMBO reports · 2026Article
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- Effects of HIIT training and HIIT combined with circuit resistance training on measures of physical fitness, miRNA expression, and metabolic risk factors in overweight/obese middle-aged women.BMC sports science, medicine & rehabilitation · 2024Article
- Enhanced CaNature communications · 2023Article
- Stx2 Induces Differential Gene Expression and Disturbs Circadian Rhythm Genes in the Proximal Tubule.Toxins · 2022Article
- Gene Expression Profiles Induced by a Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator (SPPARMα) Pemafibrate.International journal of molecular sciences · 2019Review
- Profiling Cellular Processes in Adipose Tissue during Weight Loss Using Time Series Gene Expression.Genes · 2018Article
- Secretory phospholipase AJournal of lipid research · 2017Article
- Interactions between PPAR Gamma and the Canonical Wnt/Beta-Catenin Pathway in Type 2 Diabetes and Colon Cancer.PPAR research · 2017Review
- MiR-155 Enhances Insulin Sensitivity by Coordinated Regulation of Multiple Genes in Mice.PLoS genetics · 2016Article
- Developmental bisphenol A (BPA) exposure leads to sex-specific modification of hepatic gene expression and epigenome at birth that may exacerbate high-fat diet-induced hepatic steatosis.Toxicology and applied pharmacology · 2015Article
- ZBTB2 increases PDK4 expression by transcriptional repression of RelA/p65.Nucleic acids research · 2015Article
- Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obese C57BL/6J mice.Journal of lipid research · 2014Article
- The role of pyruvate dehydrogenase kinase in diabetes and obesity.Diabetes & metabolism journal · 2014Review
- Regulation of pyruvate metabolism in metabolic-related diseases.Reviews in endocrine & metabolic disorders · 2014Review
- The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility.Nutrition & metabolism · 2014Article
- Nuclear corepressors mediate the repression of phospholipase A2 group IIa gene transcription by thyroid hormone.The Journal of biological chemistry · 2013Article
- Role of sirtuin 1 in the regulation of hepatic gene expression by thyroid hormone.The Journal of biological chemistry · 2013Article
- Genetic inactivation of pyruvate dehydrogenase kinases improves hepatic insulin resistance induced diabetes.PloS one · 2013Article
- Transcriptional regulation of pyruvate dehydrogenase kinase.Diabetes & metabolism journal · 2012Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
The conversion of pyruvate to acetyl-CoA in mitochondria is catalyzed by the pyruvate dehydrogenase complex (PDC). Activity of PDC is inhibited by phosphorylation via the pyruvate dehydrogenase kinases (PDKs). Here, we examined the regulation of Pdk4 gene expression by the CCAAT/enhancer-binding protein β (C/EBPβ). C/EBPβ modulates the expression of multiple hepatic genes including those involved in metabolism, development, and inflammation. We found that C/EBPβ induced Pdk4 gene expression and decreased PDC activity. This transcriptional induction was mediated through two C/EBPβ binding sites in the Pdk4 promoter. C/EBPβ participates in the hormonal regulation of gluconeogenic genes. Previously, we reported that Pdk4 was induced by thyroid hormone (T(3)). Therefore, we investigated the role of C/EBPβ in the T(3) regulation of Pdk4. T(3) increased C/EBPβ abundance in primary rat hepatocytes. Knockdown of C/EBPβ with siRNA diminished the T(3) induction of the Pdk4 and carnitine palmitoyltransferase (Cpt1a) genes. CPT1a is an initiating step in the mitochondrial oxidation of long chain fatty acids. Our results indicate that C/EBPβ stimulates Pdk4 expression and participates in the T(3) induction of the Cpt1a and Pdk4 genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.