ArticleParasitology international2011
The expression of REG 1A and REG 1B is increased during acute amebic colitis.
Article in Parasitology international, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 54 citations in OpenAlex.
- REG/Reg family proteins: mediating gut microbiota homeostasis and implications in digestive diseases.Gut microbes · 2025Review
- Pancreatic stone protein inhibits pyroptosis of pancreatic acinar cells in sepsis-associated pancreatic injury.Frontiers in medicine · 2025Article
- Multiplexed immunohistochemical evaluation of small bowel inflammatory and epithelial parameters in environmental enteric dysfunction.The American journal of clinical nutrition · 2024Article
- Pathogenicity and virulence ofVirulence · 2023Review
- Multi-Organ Nutrigenomic Effects of Dietary Grapes in a Mouse Model.Antioxidants (Basel, Switzerland) · 2023Article
- Entamoeba histolytica HM-1: IMSS gene expression profiling identifies key hub genes, potential biomarkers, and pathways in Amoebiasis infection: a systematic network meta-analysis.Bioscience reports · 2022Article
- Associations between Gut Microbiota and Intestinal Inflammation, Permeability and Damage in Young Malawian Children.Journal of tropical pediatrics · 2022Article
- The IL-33-ILC2 pathway protects from amebic colitis.Mucosal immunology · 2022Article
- Infection WithFrontiers in cellular and infection microbiology · 2022Article
- The Potential Role of REG Family Proteins in Inflammatory and Inflammation-Associated Diseases of the Gastrointestinal Tract.International journal of molecular sciences · 2021Review
- Host Protective Mechanisms to Intestinal Amebiasis.Trends in parasitology · 2021Review
- MicroRNA Expression and Intestinal Permeability in Children Living in a Slum Area of Bangladesh.Frontiers in molecular biosciences · 2021Article
- Molecular Changes in the Non-Inflamed Terminal Ileum of Patients with Ulcerative Colitis.Cells · 2020Article
- Transcriptomic analysis of enteropathy in Zambian children with severe acute malnutrition.EBioMedicine · 2019Article
- Glutathione peroxidase-1 inhibits transcription of regenerating islet-derived protein-2 in pancreatic islets.Free radical biology & medicine · 2019Article
- Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response.Nature communications · 2019Article
- Parasite-Produced MIF Cytokine: Role in Immune Evasion, Invasion, and Pathogenesis.Frontiers in immunology · 2019Review
- Four Decades After the Discovery of Regenerating Islet-Derived (Reg) Proteins: Current Understanding and Challenges.Frontiers in cell and developmental biology · 2019Review
- Tissue Destruction Caused byCurrent clinical microbiology reports · 2019Review
- Expression of human REG family genes in inflammatory bowel disease and their molecular mechanism.Immunologic research · 2018Article
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
Entamoeba histolytica, a protozoan parasite, is an important cause of diarrhea and colitis in the developing world. Amebic colitis is characterized by ulceration of the intestinal mucosa. We performed microarray analysis of intestinal biopsies during acute and convalescent amebiasis in order to identify genes potentially involved in tissue injury or repair. Colonic biopsy samples were obtained from 8 patients during acute E. histolytica colitis and again 60 days after recovery. Gene expression in the biopsies was evaluated using microarray, and confirmed by reverse transcriptase quantitative polymerase chain reaction (RT-qPCR). REG 1A and REG 1B were the most up-regulated of all genes in the human intestine in acute versus convalescent E. histolytica disease: as determined by microarray, the levels of induction were 7.4-fold and 10.7 fold for REG 1A and B; p=0.003 and p=0.006 respectively. Increased expression of REG 1A and REG 1B protein in the colonic crypt epithelial cells during acute amebiasis was similarly observed by immunohistochemistry. Because REG 1 protein is anti-apoptotic and pro-proliferative, and since E. histolytica induces apoptosis of the intestinal epithelium as part of its disease process, we next tested if REG 1 might be protective during amebiasis by preventing parasite-induced apoptosis. Intestinal epithelial cells from REG 1-/- mice were found to be more susceptible to spontaneous, and parasite-induced, apoptosis in vitro (p=0.03). We concluded that REG 1A and REG 1B were upregulated during amebiasis and may function to protect the intestinal epithelium from parasite-induced apoptosis.
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