ArticleBiochemical and biophysical research communications2011
Characterization of the novel interaction between muskelin and TBX20, a critical cardiogenic transcription factor.
Article in Biochemical and biophysical research communications, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- A Missense Variant inGenes · 2021Article
- The mammalian CTLH complex is an E3 ubiquitin ligase that targets its subunit muskelin for degradation.Scientific reports · 2019Article
- MKLN1 splicing defect in dogs with lethal acrodermatitis.PLoS genetics · 2018Article
- Studies of recombinant TWA1 reveal constitutive dimerization.Bioscience reports · 2017Article
- Putative Breast Cancer Driver Mutations in TBX3 Cause Impaired Transcriptional Repression.Frontiers in oncology · 2015Article
- The Cdk5 activator P39 specifically links muskelin to myosin II and regulates stress fiber formation and actin organization in lens.Experimental cell research · 2015Article
- CHD7 interacts with BMP R-SMADs to epigenetically regulate cardiogenesis in mice.Human molecular genetics · 2014Article
- Sertad1 encodes a novel transcriptional co-activator of SMAD1 in mouse embryonic hearts.Biochemical and biophysical research communications · 2013Article
- Alternative splicing of T-box transcription factor genes.Biochemical and biophysical research communications · 2011Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The genetic regulation necessary for the formation of a four-chambered heart is tightly regulated by transcription factors such as TBX20, a member of the T-box (TBX) transcription factor family. TBX20 is critical for proper cardiogenesis and is expressed in the heart throughout development. Missense mutations in TBX20 have been found in patients with congenital heart defects (CHD). Characterization of modifiers of TBX20 activity will help elucidate the genetic mechanisms of heart development and CHD. A yeast two-hybrid assay screening an embryonic mouse heart cDNA library with TBX20b as bait was used to identify potential modifiers of TBX20 activity and identified an interaction with muskelin (MKLN1), a primarily cytoplasmic protein with potential roles in signal transduction machinery scaffolding and nucleocytoplasmic protein shuttling. In cellular studies, MKLN1 directly binds to the T-box DNA-binding domain of only the TBX20b isoform by its kelch repeats domain. Immunostaining of mammalian cells transfected with tagged TBX20b and MKLN1 revealed colocalization primarily in the cytoplasm. Immunohistochemistry analysis of embryonic mouse hearts reveals coexpression in the developing endocardial valvular and myocardial interventricular cells. This novel interaction between TBX20b and MKLN1 may help elucidate new regulatory mechanisms within heart development.
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