SynthesisOrphanet journal of rare diseases2011
Parental risk factors and anorectal malformations: systematic review and meta-analysis.
Synthesis in Orphanet journal of rare diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02624232 (Long-term Outcome in Patients Operated for Congenital Anorectal Malformations), which is not on this map. Cited by 34 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Long-term Outcome in Patients Operated for Congenital Anorectal Malformations
Who cites it
34 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Diabetes and anti-diabetic interventions and the risk of gynaecological and obstetric morbidity: an umbrella review of the literature.BMC medicine · 2023Pooled it
- Environmental and Genetic Risk Factors of Congenital Anomalies: an Umbrella Review of Systematic Reviews and Meta-Analyses.Journal of Korean medical science · 2021Pooled it
- Can Anorectal Atresia Be Diagnosed in the First Trimester of Pregnancy? A Systematic Literature Review.Medicina (Kaunas, Lithuania) · 2020Pooled it
- Maternal drug use and the risk of anorectal malformations: systematic review and meta-analysis.Orphanet journal of rare diseases · 2018Pooled it
- Familial, environmental, and pregnancy-related risk factors for anorectal malformations in Pakistani newborns: a hospital-based case-control study.BMC pediatrics · 2026Article
- A case of pregnancy following surgery for imperforate anus with absent prostate and seminal vesicles.International journal of surgery case reports · 2026Article
- A five year experience of anorectal malformation surgical reconstrunctions and functional outcome associated factors in Eastern Africa.BMC pediatrics · 2025Article
- Anorectal malformations.Nature reviews. Disease primers · 2024Review
- Article
- Maternal diabetes negatively impacts fetal health.Open biology · 2022Review
- Pregnancy Care for Patients With Super Morbid Obesity.Frontiers in pediatrics · 2022Review
- The Association of Prepregnancy Body Mass Index with Pregnancy Outcomes in Chinese Women.Journal of diabetes research · 2022Article
- Case Report: A Case Series of Rare High-Type Anorectal Malformations With Perineal Fistula: Beware of Urethral Involvement.Frontiers in surgery · 2021Article
- Risk factors associated with anorectal malformations development. A case-control study.Saudi medical journal · 2020Article
- An epigenetic association of malformations, adverse reproductive outcomes, and fetal origins hypothesis related effects.Journal of assisted reproduction and genetics · 2018Review
- Article
- Paternal smoking and germ cell death: A mechanistic link to the effects of cigarette smoke on spermatogenesis and possible long-term sequelae in offspring.Molecular and cellular endocrinology · 2016Review
- Currarino Syndrome and the Effect of a Large Anterior Sacral Meningocele on Distal Colostogram in an Anorectal Malformation.Journal of radiology case reports · 2016Article
- [Risk factors for congenital anal atresia].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016Article
- Investigating paternal preconception risk factors for adverse pregnancy outcomes in a population of internet users.Reproductive health · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnorectal malformations (ARM) are rare forms of congenital uro-rectal anomalies with largely unknown causes. Besides genetic factors, prenatal exposures of the parents to nicotine, alcohol, caffeine, illicit drugs, occupational hazards, overweight/obesity and diabetes mellitus are suspected as environmental risk factors.
methodsRelevant studies published until August 2010 were identified through systematic search in PubMed, EMBASE, ISI Web of Knowledge and the Cochrane Library databases. Furthermore, related and cross-referencing publications were reviewed. Pooled odds ratios (95% confidence intervals) were determined to quantify associations of maternal and paternal smoking, maternal alcohol consumption, underweight (body mass index [BMI] < 18.5), overweight (BMI 25-29.9), obesity (BMI ≥30) and maternal diabetes mellitus with ARM using meta-analyses.
results22 studies that reported on the association between prenatal environmental risk factors and infants born with ARM were included in this review. These were conducted in the United States of America (n = 12), Spain (n = 2), Sweden (n = 2), the Netherlands (n = 2), Japan (n = 1), France (n = 1), Germany (n = 1) and Hungary (n = 1). However, only few of these studies reported on the same risk factors. Studies were heterogeneous with respect to case numbers, control types and adjustment for covariates. Consistently increased risks were observed for paternal smoking and maternal overweight, obesity and diabetes, but not for maternal smoking and alcohol consumption. In meta-analyses, pooled odds ratios (95% confidence intervals) for paternal smoking, maternal overweight, obesity, pre-gestational and gestational diabetes were 1.53 (1.04-2.26), 1.25 (1.07-1.47), 1.64 (1.35-2.00), 4.51 (2.55-7.97) and 1.81 (1.23-2.65), respectively.
conclusionEvidence on risk factors for ARM from epidemiological studies is still very limited. Nevertheless, the few available studies indicate paternal smoking and maternal overweight, obesity and diabetes to be associated with increased risks. Further, ideally large-scale multicentre and register-based studies are needed to clarify the role of key risk factors for the development of ARM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.