ReviewClinical and experimental pharmacology & physiology2012
Role of mineralocorticoid action in the brain in salt-sensitive hypertension.
Review in Clinical and experimental pharmacology & physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Primary Aldosteronism and Resistant Hypertension: A Pathophysiological Insight.International journal of molecular sciences · 2022Review
- Concurrent Primary Aldosteronism and Renal Artery Stenosis: An Overlooked Condition Inducing Resistant Hypertension.Frontiers in cardiovascular medicine · 2022Article
- Article
- Role of Mineralocorticoid and Angiotensin Type 1 Receptors in the Paraventricular Nucleus in Angiotensin-Induced Hypertension.Frontiers in physiology · 2021Article
- The differences in brain stem transcriptional profiling in hypertensive ISIAH and normotensive WAG rats.BMC genomics · 2019Article
- Mineralocorticoid Receptors, Neuroinflammation and Hypertensive Encephalopathy.Cellular and molecular neurobiology · 2019Review
- Potential Deep Brain Stimulation Targets for the Management of Refractory Hypertension.Frontiers in neuroscience · 2019Review
- Central nervous system neuroplasticity and the sensitization of hypertension.Nature reviews. Nephrology · 2018Review
- Effect of dietary salt intake on epithelial NaPhysiological reports · 2018Article
- Stress, Genes, and Hypertension. Contribution of the ISIAH Rat Strain Study.Current hypertension reports · 2018Review
- Genome-wide transcriptome analysis of hypothalamus in rats with inherited stress-induced arterial hypertension.BMC genetics · 2016Article
- Localisation of 11β-Hydroxysteroid Dehydrogenase Type 2 in Mineralocorticoid Receptor Expressing Magnocellular Neurosecretory Neurones of the Rat Supraoptic and Paraventricular Nuclei.Journal of neuroendocrinology · 2015Article
- Hypercortisolism in obesity-associated hypertension.Current hypertension reports · 2014Review
- Contribution of aldosterone to cardiovascular and renal inflammation and fibrosis.Nature reviews. Nephrology · 2013Review
- 11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action.Physiological reviews · 2013Review
- A mutation in the start codon of γ-crystallin D leads to nuclear cataracts in the Dahl SS/Jr-Ctr strain.Mammalian genome : official journal of the International Mammalian Genome Society · 2013Article
- Angiotensin-converting enzyme inhibitor does not suppress renal angiotensin II levels in angiotensin I-infused rats.Journal of pharmacological sciences · 2013Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
1. The mechanisms by which excessive salt causes hypertension involve more than retention of sodium and water by the kidneys and are far from clear. Mineralocorticoids act centrally to increase salt appetite, sympathetic drive and vasopressin release, resulting in hypertension that is prevented by the central infusion of mineralocorticoid receptor (MR) antagonists. The MR has similar affinity for aldosterone and the glucocorticoids corticosterone or cortisol. Specificity is conferred in transport epithelia by the colocalization of the MR with 11β-hydroxysteroid dehydrogenase Type 2. Coexpression also occurs in some neurons, notably those of the nucleus tractus solitarius that are activated by sodium depletion and aldosterone and mediate salt-seeking behaviour. 2. The salt-induced hypertension of the Dahl salt-sensitive rat is mitigated by the central infusion of a mineralocorticoid antagonist even though circulating aldosterone is normal or reduced in salt-sensitive (SS). Contrary to reports that salt appetite in the Dahl salt-sensitive rat is depressed, we found that it is increased compared with that in Spraque-Dawley rats. 3. Extra-adrenal aldosterone synthesis in the brain occurs in minute amounts that could only be relevant locally. Expression of aldosterone synthase mRNA and aldosterone concentrations in the brain of Dahl salt-sensitive rats are increased compared with Spraque-Dawley rats. The central infusion of inhibitors of aldosterone synthesis lowers salt-induced hypertension in the Dahl salt-sensitive rat, suggesting a role for excessive Dahl salt-sensitive synthesis in the brain. Brain MR, particularly those in the paraventricular nuclei, regulate inflammatory processes that are exacerbated by sodium and lead to cardiovascular dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.