ArticleTissue engineering. Part C, Methods2011
Laser printing of three-dimensional multicellular arrays for studies of cell-cell and cell-environment interactions.
Article in Tissue engineering. Part C, Methods, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 223 citations in OpenAlex.
- A Reproducible MRI-Based Pipeline for Longitudinal Tracking of Laser-Assisted Bioprinted Cells in Three-Dimensional Constructs.NMR in biomedicine · 2026Article
- Programmable viscoelastic hydrogels exhibit antimicrobial and regenerative properties to promote cell migration, wound healing, and tissue remodeling.Microsystems & nanoengineering · 2026Article
- Cellnet technology to generate 3D, functional, single-cell networks in custom architectures within collagen.Biofabrication · 2025Article
- Bioengineering methods for vascularizing organoids.Cell reports methods · 2024Review
- Reconstructing Spatial Transcriptomics at the Single-cell Resolution with BayesDeep.bioRxiv : the preprint server for biology · 2023Article
- Application of 3D Bioprinting in Liver Diseases.Micromachines · 2023Review
- Review
- Dynamics of single cell femtosecond laser printing.Biomedical optics express · 2023Article
- Out of Box Thinking to Tangible Science: A Benchmark History of 3D Bio-Printing in Regenerative Medicine and Tissues Engineering.Life (Basel, Switzerland) · 2023Review
- Bioprinting Technologies and Bioinks for Vascular Model Establishment.International journal of molecular sciences · 2023Review
- Up-to-date progress in bioprinting of bone tissue.International journal of bioprinting · 2023Review
- Laser Bioprinting of Cells Using UV and Visible Wavelengths: A Comparative DNA Damage Study.Bioengineering (Basel, Switzerland) · 2022Article
- Advances in three-dimensional bioprinted stem cell-based tissue engineering for cardiovascular regeneration.Journal of molecular and cellular cardiology · 2022Review
- Isolation and Culture of Single Microbial Cells by Laser Ejection Sorting Technology.Applied and environmental microbiology · 2022Article
- Advances of 3D Printing in Vascularized Organ Construction.International journal of bioprinting · 2022Review
- 3D bioprinted mesenchymal stromal cells in skin wound repair.Frontiers in surgery · 2022Review
- Controlling Droplet Impact Velocity and Droplet Volume: Key Factors to Achieving High Cell Viability in Sub-Nanoliter Droplet-based Bioprinting.International journal of bioprinting · 2022Article
- Capillary-like Formations of Endothelial Cells in Defined Patterns Generated by Laser Bioprinting.Micromachines · 2021Article
- Bioprinting of Stem Cells in Multimaterial Scaffolds and Their Applications in Bone Tissue Engineering.Sensors (Basel, Switzerland) · 2021Review
- Recent Advancements in 3D Printing and Bioprinting Methods for Cardiovascular Tissue Engineering.Bioengineering (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Utilization of living cells for therapies in regenerative medicine requires a fundamental understanding of the interactions between different cells and their environment. Moreover, common models based on adherent two-dimensional cultures are not appropriate to simulate the complex interactions that occur in a three-dimensional (3D) cell-microenvironment in vivo. In this study, we present a computer-aided method for the printing of multiple cell types in a 3D array using laser-assisted bioprinting. By printing spots of human adipose-derived stem cells (ASCs) and endothelial colony-forming cells (ECFCs), we demonstrate that (i) these cell spots can be arranged layer-by-layer in a 3D array; (ii) any cell-cell ratio, cell quantity, cell-type combination, and spot spacing can be realized within this array; and (iii) the height of the 3D array is freely scalable. As a proof of concept, we printed separate spots of ASCs and ECFCs within a 3D array and observed cell-cell interactions in vascular endothelial growth factor-free medium. It has been demonstrated that direct cell-cell contacts trigger the development of stable vascular-like networks. This method can be applied to study complex and dynamic relationships between cells and their local environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.