ArticlePharmaceutical research2011
Turbidity spectroscopy for characterization of submicroscopic drug carriers, such as nanoparticles and lipid vesicles: size determination.
Article in Pharmaceutical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 53 citations in OpenAlex.
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- Stimulation of ABCB4/MDR3 ATPase activity requires an intact phosphatidylcholine lipid.Journal of lipid research · 2020Article
- Development of Novel High-Resolution Size-Guided Turbidimetry-Enabled Particle Purification Liquid Chromatography (PPLC): Extracellular Vesicles and Membraneless Condensates in Focus.International journal of molecular sciences · 2020Article
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- A Method for High-Throughput Measurements of Viscosity in Sub-micrometer-Sized Membrane Systems.Chembiochem : a European journal of chemical biology · 2020Article
- Core-Shell Modeling of Light Scattering by Vesicles: Effect of Size, Contents, and Lamellarity.Biophysical journal · 2019Article
- Evaluation of exfoliation degree of montmorillonite in aqueous dispersions through turbidity measurement.RSC advances · 2018Article
- In Vitro Anti/Pro-oxidant Activities of R. ferruginea Extract and Its Effect on Glioma Cell Viability: Correlation with Phenolic Compound Content and Effects on Membrane Dynamics.The Journal of membrane biology · 2018Article
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Authors and funding
2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeTo apply UV/Vis spectrometry for characterization of submicroscopic drug carriers, such as nanoparticles and lipid vesicles.
methodsWe first investigated theoretically, within the framework of the Rayleigh-Gans-Debye approximation (RGDA), parameters affecting turbidity spectrum, τ(λ), of nanosized light scatterers. We then analyzed, within the framework of the RGDA, experimental turbidity spectra (λ = 400-600 nm) of extruded unilamellar vesicle (70 nm ≤ 2r ≤ 110 nm) suspensions to derive vesicle size, using dynamic light scattering results for comparison. We similarly studied the preparations polydispersity and lamellarity and monitored vesicle size changes.
resultsTurbidimetry suffices for accurate, fast, and viscosity-independent characterization of submicroscopic particles. Analysis of turbidity spectra, or more precisely wavelength exponent spectra (derivatives of logarithmic turbidity spectra), yielded similar average radii (r = 54.2 ± 0.2 nm; 46.0 ± 0.2 nm; 35.5 ± 0.1 nm) as dynamic light scattering (r = 55.9 ± 1.5 nm; 46.1 ± 0.4 nm; 36.1 ± 0.4 nm). Both methods also revealed similar suspension polydispersity and cholate-induced vesicle size changes in a few nanometer range.
conclusionDespite its experimental simplicity, the widely accessible turbidimetric method provides accurate size values and is suitable for (continuous) monitoring size stability, or sameness, of submicroscopic drug carriers.
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